Clinical and endocrinologic study of continuous levonorgestrel administration from subcutaneous solid polydimethylsiloxane rods

S Roy, F Stanczyk, DR Mishell Jr, M Lumkin… - Contraception, 1980 - Elsevier
Three solid polydimethylsiloxane (Silastic®) rods containing levonorgestrel were inserted
into the subcutaneous tissue of the volar aspect of the forearm of 8 women. Serum samples …

Plasma levonorgestrel and progesterone levels in women treated with silastic covered rods containing levonorgestrel

HB Croxatto, S Diaz, A Brandeis, M Pavez… - Contraception, 1985 - Elsevier
Levonorgestrel and progesterone plasma levels were measured in women bearing
levonorgestrel subdermal implants. Two groups using four or six levonorgestrel covered …

Bleeding and serum d-norgestrel, estradiol and progesterone patterns in women using d-norgestrel subdermal polysiloxane capsules for contraception

DE Moore, S Roy, FZ Stanczyk, DR Mishell Jr - Contraception, 1978 - Elsevier
Six dimethyl polysiloxane (Silastic R) 2 capsules, each containing 33.9 mg d-norgestrel,
were implanted subcutaneously into the forearm of 12 women with regular menstrual cycles …

First year clinical experience with six levonorgestrel rods as subdermal contraception

A Faundes, VB de Mejias, P Leon, D Robertson… - Contraception, 1979 - Elsevier
Previous clinical experience with six levonorgestrel subdermal capsules showed a very
good contraceptive effectiveness and continuation rate, but with a high proportion of …

Long-term reversible contraception with levonorgestrel-releasing Silastic rods

S Roy, DR Mishell Jr, DN Robertson, RM Krauss… - American journal of …, 1984 - Elsevier
Subcutaneously placed Silastic capsules containing levonorgestrel are effective for 5 years
and have a higher continuation rate than other methods of reversible contraception. Six 3 cm …

Menstrual blood loss with contraceptive subdermal levonorgestrel implants

CG Nilsson, P Holma - Fertility and sterility, 1981 - Elsevier
Six Silastic capsules each containing 30 mg of levonorgestrel were inserted subcutaneously
in the left forearms of 13 volunteer women for contraceptive purposes. Quantitative …

Levonorgestrel plasma levels during continuous administration with different models of subdermal implants

F Alvarez, V Brache, A Faundes, EDB Johansson… - Contraception, 1983 - Elsevier
Plasma concentrations of levonorgestrel were determined in women using subdermal
levonorgestrel implants. One group had 6 Silastic® capsules†(NORPLANT), one group had …

Contraception with subdermal implants releasing levonorgestrel: a clinical and pharmacological study

SE Olsson - Acta Obstetricia et Gynecologica Scandinavica, 1987 - Taylor & Francis
Two methods for release of levonorgestrel from polydimethylsiloxane (SilasticR) subdermal
implants for contraception were studied. The first system consists of six 3 cm long SilasticR …

Release rates of levonorgestrel from SilasticR capsules, homogeneous rods and covered rods in humans

DN Robertson, I Sivin, HA Nash, J Braun, J Dinh - Contraception, 1983 - Elsevier
Three forms of subdermal implants containing levonorgestrel are described. These are:
capsules, in which the powdered drug is sealed inside of lengths of Medical Grade Silastic …

Inhibition of the positive feedback of oestradiol during treatment with subcutaneous implants of d-norgestrel

E Weiner, EDB Johansson, L Wide - Contraception, 1976 - Elsevier
Dimethylpolysiloxane homogenously impregnated with d-norgestrel, forming rods
containing 40 mg d-norgestrel, was placed subcutaneously in the gluteal region. One such …