The biological functions and signaling mechanisms of the p75 neurotrophin receptor

BR Kraemer, SO Yoon, BD Carter - Neurotrophic factors, 2014 - Springer
The p75 neurotrophin receptor (p75 NTR) regulates a wide range of cellular functions,
including programmed cell death, axonal growth and degeneration, cell proliferation …

Multi‐tasking by the p75 neurotrophin receptor: sortilin things out?

FC Bronfman, M Fainzilber - EMBO reports, 2004 - embopress.org
Signalling by the p75 neurotrophin receptor has been implicated in diverse neuronal
responses, including increased differentiation or survival, inhibition of regeneration, and …

The p75 neurotrophin receptor: at the crossroad of neural repair and death

RB Meeker, KS Williams - Neural regeneration research, 2015 - journals.lww.com
The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA,
TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury …

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling? Neuronal life, growth and death signalling are crucially regulated by intra …

S Skeldal, D Matusica, A Nykjaer, EJ Coulson - Bioessays, 2011 - Wiley Online Library
The common neurotrophin receptor (p75NTR) regulates various functions in the developing
and adult nervous system. Cell survival, cell death, axonal and growth cone retraction, and …

The p75 neurotrophin receptor: multiple interactors and numerous functions

JJ Gentry, PA Barker, BD Carter - Progress in brain research, 2004 - Elsevier
The neurotrophin receptor p75 (p75 NTR), is involved in a diverse array of cellular
responses, including apoptosis, neurite outgrowth and myelination. Stimulation of p75 NTR …

[HTML][HTML] Dynamic nature of the p75 neurotrophin receptor in response to injury and disease

R Meeker, K Williams - Journal of neuroimmune pharmacology, 2014 - Springer
Neurotrophins and their respective tropomyosin related kinase (Trk) receptors (TrkA, TrkB,
and TrkC) and the p75 neurotrophin receptor (p75 NTR) play a fundamental role in the …

The function of p75NTR in glia

AB Cragnolini, WJ Friedman - Trends in neurosciences, 2008 - cell.com
The p75 neurotrophin receptor (p75 NTR) is expressed on many cell types and can
influence a variety of cellular functions. This receptor can mediate cell survival or cell death …

Roles of glial p75NTR in axonal regeneration

XF Zhou, HY Li - Journal of neuroscience research, 2007 - Wiley Online Library
The neurotrophin receptor p75 (p75NTR) is expressed by both neurons and glia. Nerve
injury triggers up‐regulation of p75NTR in Schwann cells (SC) but not in central glia. In …

Neurotrophin signaling through the p75 neurotrophin receptor

PP Roux, PA Barker - Progress in neurobiology, 2002 - Elsevier
The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …

The p75 neurotrophin receptor

CK Underwood, EJ Coulson - The international journal of biochemistry & …, 2008 - Elsevier
The pan neurotrophin receptor (p75NTR) is best known for mediating neural cell death
during development as well as in the adult following injury, the latter making it a target for the …