Many factors affect vaccine efficacy. One of the most salient is the frequency and intervals of
vaccine administration. In this study, we assessed the vaccine administration modality for a …

The goal of this research was to study the effect of polyanhydride chemistry on the immune
response induced by a prophylactic cancer vaccine based on biodegradable polyanhydride …

One of the primary goals of our group and our collaborators here at the University of Iowa is
to develop therapeutic cancer vaccines using biodegradable and biocompatible polymer …

Tumor-specific CD8+ cytotoxic T lymphocytes (CTLs) play a critical role in an anti-tumor
immune response. However, vaccination intended to elicit a potent CD8+ T cell responses …

The sc injection of tumor Ag-derived, MHC class I-binding peptides together with cationic
poly-amino acids (eg, poly-l-arginine; pR) has been shown to protect animals against a …

Delivery of vaccine antigens with an appropriate adjuvant can trigger potential immune
responses against cancer leading to reduced tumor growth and improved survival. In this …

The primary objective of this study was to enhance the antitumor efficacy of a model cancer
vaccine through co-delivery of pentaerythritol lipid A (PELA), an immunological adjuvant …

Cancer cell vaccines with strong specificity and low tolerance have been revealed to be a
promising option for oncology treatment. Various antigen forms, including tumor cell lysate …

Virus‐like particles (VLP) from the rabbit haemorrhagic disease virus (RHDV) can deliver
tumour antigens to induce anticancer immune responses. In this study, we explored how …

Current nonviral genetic vaccine systems are less effective than viral vaccines, particularly in
cancer systems where epitopes can be weakly immunogenic and antigen-presenting cell …