Objective: The authors compared the effectiveness of cognitive therapy and
pharmacotherapy as second-step strategies for outpatients with major depressive disorder …

Objective: Treatment of major depressive disorder typically entails implementing treatments
in a stepwise fashion until a satisfactory outcome is achieved. This study sought to identify …

Objective: Adults with major depressive disorder frequently do not achieve remission with an
initial treatment. Addition of psychotherapy for patients who do not achieve remission with …

STAR* D is a multisite, prospective, randomized, multistep clinical trial of outpatients with
nonpsychotic major depressive disorder. The study compares various treatment options for …

Context Little is known about selecting among second-step medications for major
depressive disorder after intolerance or lack of remission with an initial selective serotonin …

Background Antidepressant medication prevents the return of depressive symptoms, but
only as long as treatment is continued. Objectives To determine whether cognitive therapy …

Abstract The STAR* D (Sequenced Treatment Alternatives to Relieve Depression) study
used a series of sequenced, randomized treatment trials following a first and, if needed …

Background Although clinicians frequently add a second medication to an initial, ineffective
antidepressant drug, no randomized controlled trial has compared the efficacy of this …

Objective: Premature attrition from treatment may lead to worse outcomes and compromise
the integrity of clinical trials in major depressive disorder. The purpose of this study was to …

Objective: Phase III clinical trials for depression enroll participants with major depressive
disorder according to stringent inclusion and exclusion criteria. These patients may not be …