Cardiomyocyte hypertrophy has been associated with diminished mitochondrial metabolism.
Mitochondria are crucial organelles for the production of ATP, and their morphology and …

Mitochondrial dysfunction is involved in the pathogenesis of various cardiovascular
disorders. Although mitochondrial dynamics, including changes in mitochondrial fission and …

Mitochondrial fusion and fission are essential for heart function. Abrogating mitochondrial
dynamism leads to cardiomyopathy. Excessive mitochondrial fragmentation is involved in …

Background Mitochondria constitute 30% of cell volume and are engaged in two dynamic
processes called fission and fusion, regulated by Drp-1 (dynamin related protein) and …

How mitochondrial dynamism (fission and fusion) affects mitochondrial quality control is
unclear. We uncovered distinct effects on mitophagy of inhibiting Drp1-mediated …

During myogenic differentiation the short mitochondria of myoblasts change into the
extensively elongated network observed in myotubes. The functional relevance and the …

Pathological cardiac hypertrophy begins as an adaptive response to increased workload;
however, sustained hemodynamic stress will lead it to maladaptation and eventually cardiac …

Mitochondria are dynamic organelles that constantly undergo fission, fusion, and movement.
Increasing evidence indicates that these dynamic changes are intricately related to …

Aims Mitochondria in adult cardiomyocytes exhibit static morphology and infrequent
dynamic changes, despite the high abundance of fission and fusion regulatory proteins in …

Myocardial ischemia–reperfusion (I/R) injury is one of the leading causes of death and
disability worldwide. Mitochondrial fission has been shown to be involved in cardiomyocyte …