Depression is a common and widespread psychiatric disorder. It is estimated that 10–20% of
adults in the United States experience depression in their lifetime and 3% of the population …

In the two decades since initial studies demonstrated an association between clinical
response and blood levels of tricyclic antidepressants (TCAs), measurement of serum levels …

This chapter reviews some basic clinical understanding of depression and updates the
monitoring of antidepressants. It provides a brief historical account of depressive illness, and …

Depressions being a major problem, antidepressants are one of the most frequently used
drugs in the clinical practice. Antidepressants are commonly measured in the laboratory for …

Antidepressant measurement by liquid chromatography (LC) has enhanced the therapy of
patients who are being treated with some of the first generation tricyclic antidepressants; the …

In the last twenty years, several new antidepressant drugs have been introduced in therapy;
however, the traditional tricyclic antidepressants (TCAs), which act by inhibiting the uptake of …

Depression is a psychiatric condition that affects about 120 million people worldwide and
can interfere with independence and productivity in essentially all aspects of daily life …

The body of evidence gained up to date is sufficient to indicate that high-pressure liquid
chromatography (LC) has versatility and sensitivity in abundance for analyzing tricyclic …

Tricyclic antidepressants (TCAs) are a class of drugs first discovered in the 1950s that have
traditionally been used for the treatment of major depression [1](see Figure 11.1 for …

Nearly 2 decades have passed since initial studies demonstrated a relationship between
plasma (or serum) levels of the tricyclic antidepressant drugs and clinical response. Since …