Resistance to telithromycin and off-target effects associated with the metabolic instability
present serious and challenging problems for the development of novel macrolides. Herein …

Constitutively erythromycin-resistant apathogens are more difficult to address than inducibly
resistant and efflux-resistant strains. Three series of the 4th generation 2-fluoro 9-oxime …

Conspectus Macrolides are among the most widely prescribed antibiotics, particularly for
bacterial lung infections, due to their favorable safety, oral bioavailability, and spectrum of …

A set of novel macrolones containing the flexible C8 basic linker and quinolone 3-(2′-
hydroxyethyl) carboxamido group has been prepared and structurally characterized by NMR …

Synthesis, antibacterial activity and pharmacokinetic properties of a novel class of macrolide
antibiotics—macrolones—derived from azithromycin, comprising oxygen atom (s) in the …

Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections;
however, the increasing prevalence of macrolide-resistant pathogens is a public health …

Novel sources of antibiotics are needed to address the serious threat of bacterial resistance.
Accordingly, we have launched a structure-based drug design program featuring a …

The continuing emergence of bacterial resistance has provided an incentive for recent
intensified research on macrolide antibiotics. Belonging to the macrolide family, 16 …

An efficient method for the reconstruction of the 9-dihydroerythromycin A macrolactone
skeleton has been established. The key steps are oxidative cleavage at the 11, 12-position …

A new azithromycin-based series of antibacterial macrolones is reported, which features the
use of a 4 ″-ester linked glycin for tethering the quinolone side chain to the macrolide …