Background: Findings of substantial remaining morbidity in treated major depressive
disorder (MDD) led us to review controlled trials of treatments aimed at preventing early …

Background Major depression is probably best seen as a chronically recurrent disorder, with
patients experiencing another depressive episode after remission. Therefore, attention to …

Background Antidepressant drugs can promote remission from acute depressive episodes.
Our aim was to establish how long such treatments should be continued to prevent relapse …

Objective: Continuation therapy with antidepressants is recommended for depressed
patients who have responded to initial treatment. We quantified its efficacy in preventing …

Objective: This meta-analysis reviewed data on the efficacy and effective-ness of second-
generation antidepressants for preventing major depression relapse and recurrence during …

Importance Antidepressant medication (ADM) maintenance treatment is associated with the
prevention of depressive recurrence in patients with major depressive disorder (MDD), but …

A systematic review and random-effects model network meta-analysis were conducted to
compare the efficacy, acceptability, tolerability, and safety of antidepressants to treat adults …

BackgroundPrevention of relapse and recurrence represents an important task in the
successful treatment of major depressive disorder (MDD). The aim of this meta-analysis was …

A significant clinical issue encountered after a successful acute major depressive disorder
(MDD) treatment is the relapse of depressive symptoms. Although continuing maintenance …

BackgroundAfter remission, antidepressants are often taken long term to prevent depressive
relapse or recurrence. Whether psychological interventions can be a viable alternative or …