[HTML][HTML] The E484K mutation in the SARS-CoV-2 spike protein reduces but does not abolish neutralizing activity of human convalescent and post-vaccination sera.
One year in the coronavirus disease 2019 (COVID-19) pandemic, the first vaccines are
being rolled out under emergency use authorizations. It is of great concern that newly …
being rolled out under emergency use authorizations. It is of great concern that newly …
[PDF][PDF] The effect of spike mutations on SARS-CoV-2 neutralization
C Rees-Spear, L Muir, SA Griffith, J Heaney, Y Aldon… - Cell reports, 2021 - cell.com
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show
protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the …
protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the …
[HTML][HTML] SARS-CoV-2 spike E484K mutation reduces antibody neutralisation
It is concerning that emerging variants of SARS-CoV-2 can evade neutralising antibodies
induced by previous infection or vaccination through mutations in the spike protein …
induced by previous infection or vaccination through mutations in the spike protein …
[HTML][HTML] SARS-CoV-2 variant B. 1.1. 7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines
All current vaccines for COVID-19 utilize ancestral SARS-CoV-2 spike with the goal of
generating protective neutralizing antibodies. The recent emergence and rapid spread of …
generating protective neutralizing antibodies. The recent emergence and rapid spread of …
[PDF][PDF] Infection-and vaccine-induced antibody binding and neutralization of the B. 1.351 SARS-CoV-2 variant
VV Edara, C Norwood, K Floyd, L Lai… - Cell host & …, 2021 - cell.com
The emergence of SARS-CoV-2 variants with mutations in the spike protein is raising
concerns about the efficacy of infection-or vaccine-induced antibodies. We compared …
concerns about the efficacy of infection-or vaccine-induced antibodies. We compared …
[HTML][HTML] Crucial mutations of spike protein on SARS-CoV-2 evolved to variant strains escaping neutralization of convalescent plasmas and RBD-specific monoclonal …
C Ding, J He, X Zhang, C Jiang, Y Sun… - Frontiers in …, 2021 - frontiersin.org
Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization
profile, while single amino acid mutation in the spike protein has not been confirmed in …
profile, while single amino acid mutation in the spike protein has not been confirmed in …
A high-throughput cell-and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma
C Fenwick, P Turelli, C Pellaton, A Farina… - Science Translational …, 2021 - science.org
The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific
antibodies in the serum of an individual indicates previous infection or vaccination …
antibodies in the serum of an individual indicates previous infection or vaccination …
Cross-neutralization of emerging SARS-CoV-2 variants of concern by antibodies targeting distinct epitopes on spike
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have
arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by …
arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by …
[PDF][PDF] Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization
Neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of COVID-19
vaccines and have received emergency use authorization as therapeutics. However, viral …
vaccines and have received emergency use authorization as therapeutics. However, viral …
The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity
SARS-CoV-2 can mutate to evade immunity, with consequences for the efficacy of emerging
vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant …
vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant …
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