Enantiopure vicinal halohydrins (vic-halohydrins) are highly valuable building blocks for the
synthesis of many different natural products and pharmaceuticals, and biocatalytic methods …

A stereoselective hydroxylation and enantioselective dehalogenation cascade reaction was
developed for the synthesis of optically active β-haloalcohols from halohydrocarbons. This …

Halohydrin dehalogenases are remarkable enzymes which possess promiscuous catalytic
activity and serve as potential biocatalysts for the synthesis of chiral halohydrins, epoxides …

Two robust stereocomplementary carbonyl reductases (DhCR and CgCR) were identified
through rescreening the carbonyl reductase toolbox. Five reductases were returned through …

Halohydrin dehalogenases (HHDHs) possess an unnatural activity of introducing
functionalities such as N3, CN, NO2 etc., into a molecule through the ring‐opening reaction …

Vicinal halohydrins are key building blocks to produce bioactive molecules and drugs,
especially if they can be obtained in enantiomerically pure form. In this study, we present a …

The recombinant halohydrin dehalogenase from Agrobacterium radiobacter AD1 was used
to obtain enantiomerically pure halohydrins and epoxides by kinetic resolution. By adding …

A gene encoding halohydrin dehalogenase from an alphaproteobacterium (Ab HHDH) was
identified, cloned and over-expressed in Escherichia coli. Ab HHDH was able to catalyze the …

Enantioselective reductions with enantiocomplementarity of α-haloacetophenones by
Rhodotorula glutinis CCT 2182 and Geotrichum candidum CCT 1205 afforded the …

Chiral tetrahydrofurans are prevalent structural motifs in biologically active compounds,
approved drugs and natural products, but relevant enantiocomplementary synthesis remains …