Background Recent population-based female breast cancer and prostate cancer polygenic
risk scores (PRS) have been developed. We assessed the associations of these PRS with …

Purpose BRCA1/2 mutations increase the risk of breast and prostate cancer in men.
Common genetic variants modify cancer risks for female carriers of BRCA1/2 mutations. We …

PURPOSE To provide precise age-specific risk estimates of cancers other than female
breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and …

Importance The limited data on cancer phenotypes in men with germlineBRCA1 and
BRCA2pathogenic variants (PVs) have hampered the development of evidence-based …

The role of a germ-line BRCA2 mutation in the development of prostate cancer is
established, but the clinical presentation linked to outcome for this group of men has not …

Major risks conferred by BRCA1 and BRCA2 in women are for cancers of the breast, ovary,
fallopian tube, and peritoneum. Male carriers of mutations in BRCA1 or BRCA2 are also …

Background. The risk of cancer in men from BRCA1 and BRCA2 families is relevant to
define to motivate genetic testing and optimize recommendations for surveillance. Material …

Cancer risks and tumor types in male BRCA1 and BRCA2 mutation carriers are still
unsettled. Cancer risks in men who were found to harbor a BRCA1 (n= 150) or a BRCA2 (n …

Abstract Purpose: The Breast Cancer Linkage Consortium and other family-based
ascertainments have suggested that male carriers of BRCA mutations are at increased risk …

Recently, polygenic risk scores (PRS) have been shown to be associated with certain
complex diseases. The approach has been based on the contribution of counting multiple …