A new antioxidant made from a pterostilbene functionalized graphene nanocomposite as an efficient treatment for dry eye disease

M Lin, X Sun, S Ye, Y Chen, J Gao, F Yuan… - Frontiers in …, 2022 - frontiersin.org
Dry eye disease is a common condition that affects the eyes. It is caused by problems with
the tear film and the tear dynamics. Dry eye can be caused by an increase in the number of …

Therapeutic effect and mechanism of action of pterostilbene nano drugs in dry eye models

K Li, M Lin, K Huang, J Han, L Wei, L Miao… - Experimental Eye …, 2024 - Elsevier
Dry eye disease is a multifactorial dysfunction of the tear film and ocular surface, with
etiology involving inflammation and oxidative stress on the ocular surface. Pterostilbene …

Utilization of Nitrogen-Doped Graphene Quantum Dots to Neutralize ROS and Modulate Intracellular Antioxidant Pathways to Improve Dry Eye Disease Therapy

Z Wu, W Xia, L Ou, L Zheng, B Hou, T Pan… - International Journal …, 2024 - Taylor & Francis
Purpose Patients afflicted with dry eye disease (DED) experience significant discomfort. The
underlying cause of DED is the excessive accumulation of ROS on the ocular surface. Here …

Investigating oxidation state-induced toxicity of PEGylated graphene oxide in ocular tissue using gene expression profiles

W Wu, L Yan, S Chen, Q Li, Z Gu, H Xu, ZQ Yin - Nanotoxicology, 2018 - Taylor & Francis
Graphene and its derivatives are widely used for a variety of industrial, biomedical, and
environmental applications. However, the potential harm caused by exposure of the eyes to …

Blueberry component pterostilbene protects corneal epithelial cells from inflammation via anti-oxidative pathway

J Li, R Deng, X Hua, L Zhang, F Lu, TG Coursey… - Scientific Reports, 2016 - nature.com
Blueberries have been recognized to possess protective properties from inflammation and
various diseases, but not for eye and ocular disorders. This study explores potential benefits …

A Synergistic Therapy With Antioxidant and Anti‐VEGF: Toward its Safe and Effective Elimination for Corneal Neovascularization

H Zhu, J Ye, Y Wu, Y Cheng, M Su… - Advanced …, 2024 - Wiley Online Library
Corneal neovascularization (CNV) is one of the leading causes of blindness in the world. In
clinical practice; however, it remains a challenge to achieve a noninvasive and safe …

A cerium oxide loaded glycol chitosan nano-system for the treatment of dry eye disease

F Yu, M Zheng, AY Zhang, Z Han - Journal of controlled release, 2019 - Elsevier
Dry eye (DE) disease is an uprising health epidemic that directly affects the surface of the
eye. We developed a water soluble cerium oxide loaded glycol chitosan nanoparticle as a …

Evidence of polyphenols efficacy against dry eye disease

G Favero, E Moretti, K Krajčíková, V Tomečková… - Antioxidants, 2021 - mdpi.com
Dry eye disease is a multifactorial pathology compromising the quality of life of patients,
resulting in significant damage of the ocular surface and discomfort. The current …

Evaluating the efficacy of polyglycolic acid-loading tetrandrine nanoparticles in the treatment of dry eye

T Li, J Tang, X Wu, Y Zhang, Y Du, Q Fang, J Li… - Ophthalmic …, 2023 - karger.com
Introduction: Dry eye disease (DED) is a multifactor-induced disease accompanied by
increased osmolarity of the tear film and inflammation of the ocular surface. Traditional anti …

Preparation and characterization of a pterostilbene-peptide prodrug nanomedicine for the management of dry eye

L Hu, Z Hu, Y Yu, X Ding, K Li, Q Gong, D Lin… - International Journal of …, 2020 - Elsevier
In the present study, a pterostilbene-peptide amphiphile (PS-GA-RGD) that can
spontaneously self-assemble into prodrug nanomedicine, was rationally designed and …