The persistence of drug taking despite its adverse consequences plays a central role in the
presentation, diagnosis, and impacts of addiction. Eventual recognition and appraisal of …

In drug addiction, cues previously associated with drug use can produce craving and
frequently trigger the resumption of drug taking in individuals vulnerable to relapse …

Addiction is a chronic, relapsing disorder, characterised by the long-term propensity of
addicted individuals to relapse. A major factor that obstructs the attainment of abstinence is …

The transition from recreational drug use to addiction can be conceptualized as a
pathological timeline whereby the psychological mechanisms responsible for disordered …

Drug addiction is a progressive, relapsing disease comprised of interlocking stages of
disordered motivation. Numerous animal models describing various stages of the addiction …

Recent theories of drug dependence propose that the transition from occasional recreational
substance use to harmful use and dependence results from the impact of disrupted midbrain …

Behavioural economic theories of addiction contend that greater expected value of drug
relative to alternative non-drug rewards is the core mechanism underpinning vulnerability to …

The successful treatment of substance use disorders is dependent on the establishment of a
long-term abstinent state. Relapse can be suppressed by interfering with memories of drug …

Relapse is a highly prevalent phenomenon in addiction. This paper examines the new
research on identifying biological factors that contribute to addiction relapse risk …

If neurobiology is ultimately to contribute to the development of successful treatments for
drug addiction, researchers must discover the molecular mechanisms by which drug …