Cytotoxins (or cardiotoxins; CTs) are toxins from cobra venom characterized by the three-
finger (TF) fold. CTs are on average 60-residue-long peptides, possessing as many as 4 …

Cytotoxins (or cardiotoxins, CTs) are small rigid membrane-active proteins of the threefinger
toxin (TFT) family. They comprise about 60 amino acid residues, stabilized by four …

Natural polycationic membrane-active peptides typically lack disulfide bonds and exhibit
fusion, cellpenetrating, antimicrobial activities. They are mostly unordered in solution, but …

Cardiotoxins (CTs) from snake venoms are a family of homologous highly basic proteins that
have extended hydrophobic patterns on their molecular surfaces. CTs are folded into three β …

The conformations of a number of snake venom cardiotoxins and short (60–62 residues)
neurotoxins were compared with the aid of circular dichroism spectra, sequences and …

Snake cardiotoxins are highly basic (pI> 10) small molecular weight (∼ 6.5 kDa), all β-sheet
proteins. They exhibit a broad spectrum of interesting biological activities. The secondary …

Carditoxins (CTXs) from cobra snake venoms, the basic 60–62 residue all-beta sheet
polypeptides, are known to bind to and impair the function of cell membranes. To assess the …

The crystal structure of cardiotoxin V from Taiwan cobra venom (CTX A5) has been solved at
pH 8.5 and refined to an R-factor of 20.7% for 7013 reflections [> 2σ (F)] between 8-and 2.19 …

The aim of the present study is to understand the structural features responsible for the lethal
activity of snake venom cardiotoxins. Comparison of the lethal potency of the five cardiotoxin …

Natural homologues of cobra cardiotoxins (CTXs) were classified into two structural
subclasses of group I and II based on the amino acid sequence and circular dichroism …