[HTML][HTML] Unlocking the potential of purinergic signaling in transplantation
Purinergic signaling has been recognized as playing an important role in inflammation,
angiogenesis, malignancy, diabetes and neural transmission. Activation of signaling …
angiogenesis, malignancy, diabetes and neural transmission. Activation of signaling …
[HTML][HTML] The role of ectonucleotidases CD39 and CD73 and adenosine signaling in solid organ transplantation
V Roberts, J Stagg, KM Dwyer - Frontiers in Immunology, 2014 - frontiersin.org
Extracellular adenosine is a potent immunomodulatory molecule that accumulates in states
of inflammation. Nucleotides such as adenosine triphosphate and adenosine diphosphate …
of inflammation. Nucleotides such as adenosine triphosphate and adenosine diphosphate …
[HTML][HTML] Extracellular nucleotide signaling in solid organ transplantation
S Yeudall, N Leitinger, VE Laubach - American Journal of Transplantation, 2020 - Elsevier
The role of extracellular purine nucleotides, including adenosine triphosphate (ATP) and
adenosine, as modulators of posttransplantation outcome and ischemia-reperfusion injury is …
adenosine, as modulators of posttransplantation outcome and ischemia-reperfusion injury is …
Purinergic regulation of the immune system
Cellular stress or apoptosis triggers the release of ATP, ADP and other nucleotides into the
extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling …
extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling …
[HTML][HTML] The purinergic system in allotransplantation
The purine nucleotide adenosine triphosphate (ATP) is a universal source of energy for any
intracellular reaction. Under specific physiological or pathological conditions, ATP can be …
intracellular reaction. Under specific physiological or pathological conditions, ATP can be …
Purinergic signalling in graft-versus-host disease
Allogeneic hematopoietic stem cell transplantation is used to treat blood cancers, but often
results in lethal graft-versus-host disease (GVHD). GVHD is an inflammatory disorder …
results in lethal graft-versus-host disease (GVHD). GVHD is an inflammatory disorder …
Purinergic signaling in early inflammatory events of the foreign body response: modulating extracellular ATP as an enabling technology for engineered implants and …
Purinergic signaling is a ubiquitous and vital aspect of mammalian biology in which purines—
mainly adenosine triphosphate (ATP)—are released from cells through loss of membrane …
mainly adenosine triphosphate (ATP)—are released from cells through loss of membrane …
Adenosinergic metabolism pathway: an emerging target for improving outcomes of solid organ transplantation
Extracellular nucleotides are widely recognized as crucial modulators of immune responses
in peripheral tissues. ATP and adenosine are key components of extracellular nucleotides …
in peripheral tissues. ATP and adenosine are key components of extracellular nucleotides …
Purinergic signaling during inflammation
HK Eltzschig, MV Sitkovsky… - New England Journal of …, 2012 - Mass Medical Soc
Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is
mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for …
mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for …
[HTML][HTML] Purinergic Signalling and Inflammation-Related Diseases
While acute inflammation is widely accepted as an important response mechanism of cells
against tissue injury, sustained inflammatory processes are increasingly recognized as one …
against tissue injury, sustained inflammatory processes are increasingly recognized as one …