The use of biomarkers and HPV genotyping to improve diagnostic accuracy in women with a transformation zone type 3

K Manley, A Patel, J Pawade, S Glew, K Hunt… - British Journal of …, 2022 - nature.com
Background Twenty percent of women referred to colposcopy have a type 3 transformation
zone—where colposcopic assessment for high-grade dysplasia (CIN2+) is not possible. This …

Cervical intraepithelial neoplasia in women with transformation zone type 3: cervical biopsy versus large loop excision

LW Gustafson, A Hammer… - … Journal of Obstetrics …, 2022 - Wiley Online Library
Objective To compare the proportion of cervical intraepithelial neoplasia grade 2 or higher
(CIN2+) in cervical biopsies with that in large loop excision of the transformation zone …

Evaluation of the diagnostic performance of colposcopy in the detection of cervical high-grade squamous intraepithelial lesions among women with transformation …

X Li, Y Zhao, F Xiang, X Zhang, Z Chen, M Zhang… - BMC cancer, 2024 - Springer
Background Inaccurate colposcopy diagnosis may lead to inappropriate management and
increase the incidence of cervical cancer. This study aimed to evaluate the diagnostic …

Clinical utility of p16/Ki67 dual‐stain cytology for detection of cervical intraepithelial neoplasia grade two or worse in women with a transformation zone type 3: A cross …

LW Gustafson, M Tranberg… - … Journal of Obstetrics …, 2023 - Wiley Online Library
Objective To evaluate the clinical utility of p16/Ki67 dual‐stain (DS) compared with cytology
for detecting cervical intraepithelial lesion grade two or worse (CIN2+) in women with a …

HPV 16 and HPV 18 genotyping triage in young women with borderline cytology or mild dyskaryosis: effect of age on genotype‐specific risk of high‐grade CIN

M McKenna, M McMenamin, A McDowell - Cytopathology, 2016 - Wiley Online Library
Objective Human papillomavirus (HPV) triage of borderline cytology or mild dyskaryosis is
limited by the higher prevalence of HPV in women with these findings relative to those with …

Endocervical curettage for diagnosing high-grade squamous intraepithelial lesions or worse in women with type 3 transformation zone lesions: a retrospective …

B Wei, Q Li, S Seery, Y Qiao, Y Jiang - BMC Women's Health, 2023 - Springer
Background This study aimed to assess the value of endocervical curettage (ECC) in
detecting high-grade squamous intraepithelial lesion or worse (HSIL+) in women with type 3 …

Accuracy of colposcopy management to detect CIN3 and invasive cancer in women with abnormal screening tests: results from a primary HPV screening project from …

KU Petry, A Luyten, S Scherbring - Gynecologic Oncology, 2013 - Elsevier
OBJECTIVE: Combining HPV and Pap screening achieves very good risk stratification and
sensitive detection of CIN3 and cancer (CIN3+), but poorer specificity, and may result in an …

Small lesion size measured by colposcopy may predict absence of cervical intraepithelial neoplasia in a large loop excision of the transformation zone specimen

M Munmany, L Marimon, M Cardona… - … Journal of Obstetrics …, 2017 - Wiley Online Library
Objective To evaluate whether colposcopic measurement of the lesion size at diagnosis
and/or human papillomavirus (HPV) genotyping can predict the absence of dysplasia in a …

Diagnostic accuracy of colposcopy with dynamic spectral imaging for cytology-negative/high-risk HPV positive (failed test of cure) after large loop excision of the …

C Founta, E Papagiannakis, N Ratnavelu, A Feusi… - Medicine, 2018 - journals.lww.com
After treatment for cervical intraepithelial neoplasia (CIN), in the UK women who are
cytology-negative, high-risk (HR) human papilloma virus (HPV) positive are referred to …

The impact of HPV cervical screening on negative large loop excision of the transformation zone (LLETZ): A comparative cohort study

KM Manley, AK Wills, GC Morris, JL Hogg… - Gynecologic …, 2016 - Elsevier
Objective To determine the incidence and predictors of negative large loop excision of the
transformation zone (LLETZ) following the introduction of Human Papillomavirus (HPV) …