The theory that depression is caused by a serotonin abnormality or other chemical
imbalance has become widely accepted by the public and is one prominent justification for …

It has been over 50 years since the original serotonin hypothesis was proposed by the
British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the …

The cause of mental disorders such as depression remains unknown. However, the idea
that neurotransmitter imbalances cause depression is vigorously promoted by …

The serotonin hypothesis of depression is still influential. We aimed to synthesise and
evaluate evidence on whether depression is associated with lowered serotonin …

We thank the authors of all the letters for their interest in our paper [1]. The reason our paper
is important is that the pharmaceutical industry, along with many doctors and academics …

A DECADE AGO, WE PUBLISHED an article in PLoS Medicine about the serotonin
deficiency theory of depression (Lacasse & Leo, 2005). We transposed the psychiatric …

The notion that impaired serotonin (5-HT) function can lead to clinical depression has a long
history but is still controversial. Some have argued that the 5-HT hypothesis has been …

A recent “umbrella” review examined various biomarkers relating to the serotonin system,
and concluded there was no consistent evidence implicating serotonin in the …

The “serotonin hypothesis” of clinical depression is almost 50 years old. At its simplest, the
hypothesis proposes that diminished activity of serotonin pathways plays a causal role in the …

Serotonin is a key neuromodulator known to be involved in brain development, perception,
cognition, and mood. However, unlike as with dopamine for example, a compelling unified …