Tobacco products present a deadly combination of nicotine addiction and carcinogen
exposure resulting in millions of cancer deaths per year worldwide. A plethora of smokeless …

The devastating link between tobacco products and human cancers results from a powerful
alliance of two factors—nicotine and carcinogens. Without either one of these, tobacco …

Tobacco use continues to be a major cause of cancer in the developed world, and despite
significant progress in this country in tobacco control, which is driving a decrease in cancer …

Tobacco and tobacco smoke contain a complex mixture of over 9500 chemical compounds,
many of which have been recognized as hazardous to human health by regulatory …

Much is now known about the carcinogens in cigarette smoke, their conversion to forms that
react with DNA, and the miscoding properties of the resulting DNA adducts that cause the …

Tobacco use is considered the single most important man-made cause of cancer that can be
avoided. The evidence that nicotine is involved in cancer development is reviewed and …

Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung
carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts …

Head and neck cancer (head and neck squamous cell carcinoma (HNSCC)) is a devastating
disease. Patients require intensive treatment that is often disfiguring and debilitating. Those …

The only known way to reduce cancer risk in smokers is complete cessation, but many
smokers are unable or unwilling to quit. Consequently, tobacco companies are now …

Smokeless tobacco has been proposed as a reduced risk substitute for smoking, but no
large studies have investigated exposure to the powerful carcinogen 4-(methylnitrosamino) …