Purpose: To assess the cell cycle-dependent influence of gemcitabine on ionizing radiation-
induced DNA double-strand breakage (DSB) and rejoining measured by pulsed-field gel …

To investigate the effect of gemcitabine (dFdC), a promising radiosensitizing nucleoside
analog, on the induction and repair of DNA double-strand breaks (dsbs) after ionizing …

Abstract Gemcitabine [2′, 2′-difluoro-2′-deoxycytidine (dFdCyd)] is a potent ionizing
radiation sensitizer in solid tumor cells in vitro and in vivo. Previously, we have …

Gemcitabine (dFdCyd) shows broad antitumor activity in solid tumors in chemotherapeutic
regimens or when combined with ionizing radiation (radiosensitization). While it is known …

Purpose: Mismatch repair (MMR) proficiency has been reported to either increase or
decrease radioenhancement by 24-h incubations with gemcitabine. This study aimed to …

Background Radiation-induced DNA double-strand break (DSB) repair can be tested by
using pulsed-field gel electrophoresis (PFGE) in agarose-encapsulated cells. However …

Measurement of the surviving fraction after 2 Gy (SF 2) may predict for local control of the
tumour and patients cure, but clonogenic assays are unsuitable for wider clinical application …

We compared the ability of graded-voltage gel electrophoresis (GVGE) and pulsed-field gel
electrophoresis (PFGE), to resolve DNA containing double-strand breaks (dsb) induced in …

Purpose: Gemcitabine is a new antimetabolite, structurally related to Ara-C, and is now
studied for its role as a potential radiosensitizer. The present investigation focussed on the …

The purpose of this study was to investigate the exact dose dependency and time
dependency of the radiation-enhancing effect of gemcitabine (2′, 2′ difluoro …