The Department of Medicinal Chemistry and Molecular Pharmacology's laboratory has
adopted four “bench top” bioassays which do not require higher animals to screen and direct …

Screening of crude extracts of the bark of Annona hullata showed cytotoxic and pesticidal
activities. By monitoring with brine-shrimp lethality, two novel, extremely po-tent …

Three simple bioassays developed and used at Purdue University are described. They
comprise (1) brine shrimp (Artemia salina) lethality (a general bioassay which is indicative of …

The leaves of Annona muricata have yielded eight monotetrahydrofuran Annonaceous
acetogenins. Twoof them, annomuricins A [1] and B [2], whose chemical structures were …

Bioactivity-directed fractionation of the seeds of Annona muricata L.(Annonaceae) resulted
in the isolation of five new compounds: cis-annonacin (1), cis-annonacin-10-one (2), cis …

Extracts of paw paw (Asimina triloba, Annonaceae) are among the most potent of the 3500
species of higher plants screened for bioactive compounds in our laboratories at Purdue …

Fractionation of the EtOH extract of the bark ofAsimina triloba, monitoring by brine
shrimplethality, has led to the isolation and structural elucidation of a novel highly cytotoxic …

Abst~ act-Asimicin. a new trihydroxy-bistetrahydrofuran fatty acid Y--lactone has been
isolated, using brine shrimp lethality for activitydirected fractionation, from extracts of the …

The Annonaceous acetogenins are an exciting new class of bioactive natural products
whose antitumour, pesticidal and other bioactivities are due to inhibition of electron transport …

Activity-directed fractionation of the stem bark oí Annona squamosa, monitoring with brine
shrimp lethality, led to the isolation of the highly bioactive acetogenins bul-latacin [1] and …