Iron is required for many biological processes but is also toxic in excess; thus, body iron
balance is maintained through sophisticated regulatory mechanisms. The lack of a regulated …

Iron, an essential nutrient, is required for many biological processes but is also toxic in
excess. The lack of a mechanism to excrete excess iron makes it crucial for the body to …

Despite fluctuations in dietary iron intake and intermittent losses through bleeding, the
plasma iron concentrations in humans remain stable at 10–30μM. While most of the iron …

Hepatic hormone hepcidin is a principal regulator of iron homeostasis and a pathogenic
factor in common iron disorders. Hepcidin deficiency causes iron overload in hereditary …

Inappropriate production of the iron-regulatory hormone hepcidin contributes to the
pathogenesis of common iron disorders. Absolute or relative deficiency of hepcidin causes …

▪ Abstract Hepcidin, a peptide hormone made in the liver, is the principal regulator of
systemic iron homeostasis. Hepcidin controls plasma iron concentration and tissue …

The discovery of hepcidin has provided a solid foundation for understanding the
mechanisms of systemic iron homeostasis and the aetiologies of iron disorders. Hepcidin …

Hepcidin is an important and recently discovered regulator of iron homeostasis. There is
strong evidence in support of an important role for hepcidin dysregulation in the …

Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin
production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron …

Hepcidin, the master regulator of systemic iron homeostasis, tightly influences erythrocyte
production. High hepcidin levels block intestinal iron absorption and macrophage iron …