Increasing attention has been directed towards identifying non-T-cell mechanisms as
potential therapeutic targets in rheumatoid arthritis. Synovial fibroblast (SF) activation, a …

Inflammation-induced bone destruction is the main cause of progressive joint damage in
rheumatoid arthritis (RA) and osteoarthritis (OA). In addition, depending on the tissue …

There is mounting evidence indicating that the synovial fibroblast is a direct effector of tissue
injury and matrix remodeling in inflammatory synovitis. Through the elaboration of effector …

Rheumatoid arthritis (RA) and osteoarthritis (OA) are common rheumatic disorders that
primarily involve joints. The inflammation of the synovium can be observed in both of the two …

Synovial pathophysiology is a complex and synergistic interplay of different cell populations
with tissue components, mediated by a variety of signaling mechanisms. All of these …

There is growing evidence that activated synovial fibroblasts, as part of a complex cellular
network, play an important role in the pathogenesis of rheumatoid arthritis. In recent years …

Objective Given the heterogeneity of gene expression patterns and cellular distribution
between rheumatoid arthritis (RA) synovial tissues, we sought to determine whether this …

Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease with systemic involvement
that affects about 1% of the Western population. The progressive destruction of affected …

Rheumatoid arthritis is an immune‐mediated inflammatory disease in which fibroblasts
contribute to both joint damage and inflammation. Fibroblasts are a major cell constituent of …

Synovial cells play a key role in joint destruction during chronic inflammation. In particular,
activated synovial fibroblasts (SFs) undergo intrinsic alterations leading to an aggressive …