RIASSUNTO L'effetto più devastante della crescita tumorale è rappresentato dalla diffusione
metastatica negli organi secondari. La cellula neoplastica che si distacca dal tumore di …

In spite of a good understanding of the cellular and molecular mechanisms responsible for
neoplastic transformation, most cancer therapies remain partially effective and transient …

ED03-01 The tumor tissue is composed of 2 compartments intimately associated with each
other. The first compartment constitutes the malignant cells. The second is the tumor …

In normal tissues and organs, the activities of the constituent cells are strictly restricted to the
tasks assigned to them during development. In addition they (with the exception of …

Malignancy of cancer is due to metastasis. Primary tumors of the brain are exceptional since
they kill through local invasion without formation of metastases. Colorectal and head and …

Recent advances in tumor biology led to the realization that, in order to understand the
mechanisms involved in proliferation and invasion of tumor cells, an analysis of the complex …

Metastatic dissemination consists of a sequence of events resulting in the invasion by
cancer cells of tissues located away from the primary tumour. This process is highly …

The authors review how cancer cells may cooperate in metastasis by means of
microenvironmental changes. The main mechanisms underlying this cooperation are …

Evolution of neoplastic cells has generally been regarded as a cumulative intrinsic process
resulting in altered cell characteristics enabling enhanced growth properties, evasion of …

The two biological mechanisms that determine types of malignancy are infiltration and
metastasis, for which tumour microenvironment plays a key role in developing and …