Alcohol dependence is correlated with a wide spectrum of medical, psychological,
behavioral, and social problems. Acute alcohol abuse causes damage to and functional …

Our understanding of the mechanisms involved in the development of alcohol-induced liver
disease has increased substantially in recent years. Specifically, reactive oxygen and …

Ethanol metabolism causes oxidative stress and lipid peroxidation not only in liver but also
in extra-hepatic tissues. Ethanol administration has been shown to cause oxidative …

Alcohol abuse is the leading cause of liver related morbidity and mortality. Chronic or binge
alcohol drinking causes hepatic steatosis which can develop to steatohepatitis, cirrhosis and …

The importance of oxidative stress in the development of alcoholic liver disease has long
been appreciated. The mechanism by which ethanol triggers an increase in reactive oxygen …

Toxic substances generated during the metabolism of alcohol in the liver may contribute to
the development of alcoholic liver disease. These substances include highly reactive …

Many studies have reported that alcohol produces harmful effects on several brain
structures, including the hippocampus, in both rodents and humans. The hippocampus is …

Alcohol abuse can affect more than the heart and the liver. Many observers often do not
appreciate the complex and differing aspects of alcohol's effects in pathophysiologies that …

There is strong evidence showing that chronic and excessive ethanol consumption may
enhance oxidative damage to neurons and result in cell death. Although not yet well …

Alcohol is eliminated from the body by various metabolic mechanisms. The primary enzymes
involved are aldehyde dehydrogenase (ALDH), alcohol dehydrogenase (ADH), cytochrome …