[HTML][HTML] Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

JE Horowitz, JA Kosmicki, A Damask, D Sharma… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells
via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID …

ACE 2 coding variants: a potential X-linked risk factor for COVID-19 disease

WT Gibson, DM Evans, J An, SJM Jones - BioRxiv, 2020 - biorxiv.org
Viral genetic variants are widely known to influence disease progression among infected
humans. Given the recent and rapid emergence of pandemic SARS-CoV-2 infection, the …

[HTML][HTML] Role of genetic variants and gene expression in the susceptibility and severity of COVID-19

S Choudhary, K Sreenivasulu, P Mitra… - Annals of laboratory …, 2021 - ncbi.nlm.nih.gov
Since its first report in December 2019, coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly emerged as a …

Genetic landscape of the ACE2 coronavirus receptor

Z Yang, E Macdonald-Dunlop, J Chen, R Zhai, T Li… - Circulation, 2022 - Am Heart Assoc
Background: SARS-CoV-2, the causal agent of COVID-19, enters human cells using the
ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the …

[HTML][HTML] New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis

Y Hou, J Zhao, W Martin, A Kallianpur, MK Chung… - BMC medicine, 2020 - Springer
Abstract Background Coronavirus Disease 2019 (COVID-19), caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has now been confirmed worldwide …

[HTML][HTML] Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

K Suryamohan, D Diwanji, EW Stawiski… - Communications …, 2021 - nature.com
COVID-19 is a respiratory illness caused by a novel coronavirus called SARS-CoV-2. The
viral spike (S) protein engages the human angiotensin-converting enzyme 2 (ACE2) …

Investigating the ACE2 polymorphisms in COVID‐19 susceptibility: An in silico analysis

N Pouladi, S Abdolahi - Molecular Genetics & Genomic …, 2021 - Wiley Online Library
Abstract Background Novel coronavirus (SARS‐CoV‐2) became an epidemic disease and
lead to a pneumonia outbreak first in December 2019 in Wuhan, China. The symptoms …

Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility

EW Stawiski, D Diwanji, K Suryamohan, R Gupta… - BioRxiv, 2020 - biorxiv.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus
disease (COVID-19) that has resulted in a global pandemic. It is a highly contagious positive …

[HTML][HTML] ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population

E Benetti, R Tita, O Spiga, A Ciolfi, G Birolo… - European Journal of …, 2020 - nature.com
In December 2019, an initial cluster of interstitial bilateral pneumonia emerged in Wuhan,
China. A human-to-human transmission was assumed and a previously unrecognized entity …

SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype

N Yamamoto, Y Ariumi, N Nishida, R Yamamoto… - Gene, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). The relentless spread and pathogenicity of the virus have …