Besides asbestos exposure, the factors that determine susceptibility to malignant
mesothelioma are unknown. We evaluated the risk of GSTM1 null genotype and slow …

Background Humans vary in their ability to metabolize endogenous and exogenous
compounds. Glutathione S-transferases (GSTs) and N-acetyltrans-ferases (NATs) are …

Exposure to asbestos fibers is a major risk factor for malignant pleural mesothelioma (MPM),
lung cancer, and other non-neoplastic conditions, such as asbestosis and pleural plaques …

Pleural malignant mesothelioma (MM) is a rare but extremely aggressive cancer. The limited
impact of standard therapeutic treatments on survival rates makes the identification of factors …

The role of CYP1A1, GSTM1, GSTT1, EPHX1, and NAT2 genotypes in susceptibility to
malignant mesothelioma (MM) was compared in two case-control studies, previously …

Malignant mesothelioma (MM) is a uniformly fatal tumour of mesothelial cells. MM is caused
by exposure to asbestos however most individuals with documented asbestos exposure do …

Individual response to oxidative stress, due to exposure to asbestos fibres plays a significant
role in the malignant pleural mesothelioma (MPM) etiology. The differential impact on MPM …

Differences in response to carcinogenic agents are due to the allelic variants of the genes
that control it. Key genes are those involved in the repair of the DNA damage caused by …

Given the interest in defining biomarkers of asbestos exposure and to provide insights into
asbestos-related and cell-specific mechanisms of neoplasia, the identification of gene …

Malignant mesothelioma (MM) is mainly caused by air-born asbestos but genetic
susceptibility is also suspected to be a risk factor. Recent studies suggest an increasing …