Microbiota alteration is associated with the development of stress-induced despair behavior

IA Marin, JE Goertz, T Ren, SS Rich… - Scientific reports, 2017 - nature.com
Depressive disorders often run in families, which, in addition to the genetic component, may
point to the microbiome as a causative agent. Here, we employed a combination of …

Antibiotic-induced microbiome depletion is associated with resilience in mice after chronic social defeat stress

S Wang, Y Qu, L Chang, Y Pu, K Zhang… - Journal of affective …, 2020 - Elsevier
Background The brain–gut axis plays a role in the pathogenesis of stress-related disorders
such as depression. However, the role of brain–gut axis in the resilience versus …

Identification of a signaling mechanism by which the microbiome regulates Th17 cell-mediated depressive-like behaviors in mice

EM Medina-Rodriguez, D Madorma… - American Journal of …, 2020 - Am Psychiatric Assoc
Objective: Microbiota dysbiosis has been linked to major depressive disorder, but the
mechanisms whereby the microbiota modulates mood remain poorly understood. The …

[HTML][HTML] Multi-omics data reveals the disturbance of glycerophospholipid metabolism caused by disordered gut microbiota in depressed mice

T Tian, Q Mao, J Xie, Y Wang, W Shao, Q Zhong… - Journal of advanced …, 2022 - Elsevier
Introduction Although researchers have done intensive research on depression, its
pathogenesis is still not fully explained. More and more evidence suggests that gut …

[HTML][HTML] CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation

J Wu, J Li, C Gaurav, U Muhammad, Y Chen… - General …, 2021 - ncbi.nlm.nih.gov
Background Although the link between gut microbiota and depression has been suggested,
changes of gut microbiota vary largely among individuals with depression. Aims Explore the …

Jasmine tea attenuates chronic unpredictable mild stress-induced depressive-like behavior in rats via the gut-brain axis

Y Zhang, J Huang, Y Xiong, X Zhang, Y Lin, Z Liu - Nutrients, 2021 - mdpi.com
The number of depressed people has increased worldwide. Dysfunction of the gut
microbiota has been closely related to depression. The mechanism by which jasmine tea …

The gut microbiome modulates the changes in liver metabolism and in inflammatory processes in the brain of chronic unpredictable mild stress rats

W Lv, X Wu, W Chen, Y Li, G Zhang… - Oxidative Medicine …, 2019 - Wiley Online Library
Generally, depression is the result of complex gene‐environment interactions. Recent
studies have showed that the gut microbiota can affect brain function through the microbiota …

Inflammasome signaling affects anxiety-and depressive-like behavior and gut microbiome composition

ML Wong, A Inserra, MD Lewis, CA Mastronardi… - Molecular …, 2016 - nature.com
The inflammasome is hypothesized to be a key mediator of the response to physiological
and psychological stressors, and its dysregulation may be implicated in major depressive …

Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2

Y Zhang, R Huang, M Cheng, L Wang, J Chao, J Li… - Microbiome, 2019 - Springer
Background Inflammasomes have been found to interact with the gut microbiota, and this
effect is associated with depression, but the mechanisms underlying this interaction have not …

Oral treatment with Lactobacillus reuteri attenuates depressive-like behaviors and serotonin metabolism alterations induced by chronic social defeat stress

R Xie, P Jiang, LI Lin, J Jiang, B Yu, J Rao, H Liu… - Journal of Psychiatric …, 2020 - Elsevier
Background Alterations in bidirectional gut–brain interactions are believed to be involved in
the pathogenesis of neuropsychiatric diseases. Considering the putative connections …