Abstract Cyclin-dependent kinase 12 (CDK12) phosphorylates the carboxyl-terminal domain
(CTD) of RNA polymerase II (pol II) but its roles in transcription beyond the expression of …

CDK9 is a kinase critical for the productive transcription of protein‐coding genes by RNA
polymerase II (pol II). As part of P‐TEFb, CDK9 phosphorylates the carboxyl‐terminal …

Abstract Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by
phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects …

Transcription through early-elongation checkpoints requires phosphorylation of negative
transcription elongation factors (NTEFs) by the cyclin-dependent kinase (CDK) 9. Using …

The Cdk7 subunit of TFIIH phosphorylates RNA polymerase II (Pol II) during initiation, and,
while recent studies show that inhibition of human Cdk7 negatively influences transcription …

Post-translational modifications of the transcription elongation complex provide mechanisms
to fine-tune gene expression, yet their specific impacts on RNA polymerase II regulation …

The RNA polymerase II (POLII)–driven transcription cycle is tightly regulated at distinct
checkpoints by cyclin-dependent kinases (CDKs) and their cognate cyclins. The molecular …

Cyclin-dependent kinase 9 (CDK9) and CDK12 have each been demonstrated to
phosphorylate the RNA polymerase II C-terminal domain (CTD) at serine 2 of the heptad …

Promoter-proximal pausing by RNA polymerase II (Pol II) ensures gene-specific regulation
and RNA quality control. Structural considerations suggested a requirement for initiation …

The RNA polymerase II (Pol II) C-terminal domain (CTD) serves as a docking site for
numerous proteins, bridging various nuclear processes to transcription. The recruitment of …