Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …

Ionizing irradiation can induce a multitude of alterations within the tumor microenvironment.
Unlike targeted therapies, radiation delivered to the tumor bed can prompt phenotypic …

Abstract Background Immune checkpoint inhibitors (ICIs) for solid tumors, including those
targeting programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 …

Since the approval of anti-CTLA4 therapy (ipilimumab) for late-stage melanoma in 2011, the
development of anticancer immunotherapy agents has thrived. The success of many …

Background Despite some successes with checkpoint inhibitors for treating cancer, most
patients remain refractory to treatment, possibly due to the inhibitory nature of the tumor …

Radiation therapy (RT) activates an in situ vaccine effect when combined with immune
checkpoint blockade (ICB), yet this effect may be limited because RT does not fully optimize …

Cancer immunotherapy has transformed traditional treatments, with immune checkpoint
blockade being particularly prominent. However, immunotherapy has minimal benefit for …

Immune checkpoint inhibitors (ICI) are effective in cancer treatment. A pre-existing immune
response demonstrated by significant pretreatment tumor lymphocytic infiltration is a …

Radiation therapy is a source of tumor antigen release that has the potential to serve as an
endogenous tumor vaccination event. In preclinical models radiation therapy synergizes …

Radiotherapy (RT) is a highly effective anti-cancer therapy delivered to around 50–60% of
patients. It is part of therapy for around 40% of cancer patients who are cured of their …