Normal airway mucus lines the epithelial surface and provides an important innate immune
function by detoxifying noxious molecules and by trapping and removing pathogens and …

The respiratory epithelium is lined by mucus, a gel consisting of water, ions, proteins, and
macromolecules. The major macromolecular components of mucus are the mucin …

Airway mucus constitutes a thin layer of airway surface liquid with component
macromolecules that covers the luminal surface of the respiratory tract. The major function of …

This review focuses on the role and regulation of mucin glycoproteins (mucins) in airway
health and disease. Mucins are highly glycosylated macromolecules (≥ 50% carbohydrate …

Mucus plays a vital role in protecting the lungs from environmental factors, but conversely, in
muco-obstructive airway disease, mucus becomes pathologic. In its protective role, mucus …

Mucins, major components of the extracellular mucus blanket that protect and lubricate
mammalian epithelia, are high-molecular-mass glycoconjugates (154 to> or= 7,000 kDa) …

Airway surface fluid contains two layers of mucins consisting mainly of 5 different mucin
gene products. While the outer layer contains two gel-forming mucins (MUC5AC and …

The airway mucosa is lined by a continuous epithelium comprised of multiple cell
phenotypes, several of which are secretory. Secretions produced by these cells mix with a …

Mucus hypersecretion is a phenotype associated with multiple obstructive lung diseases.
However, in spite of its nefarious reputation under pathologic conditions, there are …

Mucus is essential for protection of the airways; however, in chronic airway disease mucus
hypersecretion is an important factor in morbidity and mortality. The properties of the mucus …