Vesicular structures called microvesicles (MVs) that are shed from the surfaces of cancer
cells are capable of transferring oncogenic cargo to recipient cancer cells, as well as to …

A novel form of cell-to-cell communication involving the formation and shedding of large
vesicular structures, called microvesicles (MVs), from the surfaces of highly aggressive forms …

Most cancer patients die as a result of metastasis, thus it is important to understand the
molecular mechanisms of dissemination, including intra-and extravasation. Although the …

Rho GTPases are involved in the acquisition of all the hallmarks of cancer, which comprise 6
biological capabilities acquired during the development of human tumors. The hallmarks …

The Rho proteins are Ras-related guanosine triphosphatases (GTPases) that function in
cytoskeletal reorganization, cell migration, and stress fiber and focal adhesion formation …

Background The invasion of glioblastoma cells into regions of the normal brain is a critical
factor that limits current therapies for malignant astrocytomas. Previous work has identified …

Background Relatively few genes have been shown to directly affect the metastatic
phenotype of breast cancer epithelial cells in vivo. The Rho family of proteins, including the …

In vitro and in vivo studies and evidence from human tumors have long implicated Rho
GTPase signaling in the formation and dissemination of a range of cancers. Recently next …

Rho GTPases are well known to regulate cell motility through activation of a variety of
downstream effector proteins, including enzymes, adaptor proteins and actin nucleators. The …

The Rho family GTPases RhoA, RhoB, and RhoC regulate the actin cytoskeleton, cell
movement, and cell growth. Unlike Ras, up-regulation or overexpression of these GDP/GTP …