This study quantifies myocardial transfection following percutaneous retrograde coronary
venous delivery (RCVD) of a plasmid encoding human Del‐1. RCVD of Del‐1, GFP plasmid …

Myocardial delivery of genes holds great promise for treating many heart diseases; however,
the optimal delivery technique, which maximizes safety and efficacy, has not been …

Transfer of genes encoding therapeutic proteins into the myocardium shows great potential
for treatment of coronary artery disease. To quantitatively elucidate the behavior of plasmid …

Therapeutic and research applications of direct gene transfer in the coronary vasculature
are limited by varying transgene activity found in the vessel wall. It remains to be determined …

Catheter-based percutaneous transluminal gene delivery (PTGD) into the coronary artery
still falls behind the expectations of an efficient myocardial gene delivery system. In this …

Clinical reports suggest that intracoronary delivery of adenoviruses encoding angiogenic
growth factors, or their transactivators, has a therapeutic benefit. However there has not …

In patients in whom antianginal medications fail to provide sufficient symptomatic relief,
additional interventions such as angioplasty or bypass surgery may be required. Although …

Background and Aim: Local modulation of myocardial function by gene transfer or cell
depositions constitutes a potential method of cardiac treatment. This study tested the …

Objectives: We sought to study adenoviral gene delivery using percutaneous selective
pressure-regulated retroinfusion and to compare it directly with surgical and percutaneous …

Background—It is unclear what is the most efficient vector and growth factor for induction of
therapeutic vascular growth in the heart. Furthermore, the histological nature of …