Critical review on anti‐inflammation effects of saponins and their molecular mechanisms

T Wijesekara, J Luo, B Xu - Phytotherapy Research, 2024 - Wiley Online Library
This review highlights the increasing interest in one of the natural compounds called
saponins, for their potential therapeutic applications in addressing inflammation which is a …

Health benefits of saponins and its mechanisms: perspectives from absorption, metabolism, and interaction with gut

Y Zhang, R Hao, J Chen, S Li, K Huang… - Critical Reviews in …, 2023 - Taylor & Francis
Saponins, consisting of sapogenins as their aglycones and carbohydrate chains, are widely
found in plants and some marine organisms. Due to the complexity of the structure of …

Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research

FRS Passos, HG Araújo-Filho, BS Monteiro… - Phytomedicine, 2022 - Elsevier
Background Saponins are glycosides which, after acid hydrolysis, liberate sugar (s) and an
aglycone (sapogenin) which can be triterpenoid or steroidal in nature. Steroidal saponins …

Integrated microbiomic and metabolomics insight into the ameliorating mechanisms of dietary Polygonatum cyrtonema saponin on ulcerative colitis

J Xiao, L Xie, B Zheng, Y Chen, J Xie, H Huang, X Hu… - Food Bioscience, 2024 - Elsevier
The occurrence and evolution of colitis can cause prejudicial damage to the intestinal
barrier, with studies reporting positive effects of saponins on intestinal inflammation …

[HTML][HTML] Potential Immunoregulatory Mechanism of Plant Saponins: A Review

L Shen, H Luo, L Fan, X Tian, A Tang, X Wu, K Dong… - Molecules, 2023 - mdpi.com
Saponins are extracted from different parts of plants such as seeds, roots, stems, and leaves
and have a variety of biological activities including immunomodulatory, anti-inflammatory …

[HTML][HTML] Perspectives on saponins: food functionality and applications

YP Timilsena, A Phosanam, R Stockmann - International Journal of …, 2023 - mdpi.com
Saponins are a diverse group of naturally occurring plant secondary metabolites present in
a wide range of foods ranging from grains, pulses, and green leaves to sea creatures. They …

A review of saponin intervention in metabolic syndrome suggests further study on intestinal microbiota

Z Luo, W Xu, Y Zhang, L Di, J Shan - Pharmacological research, 2020 - Elsevier
Metabolic syndrome (MetS) is a series of symptoms including insulin resistance, obesity,
dyslipidemia, elevated fasting blood glucose levels, and hepatic steatosis. As a key criterion …

Immunoadjuvant and anti-inflammatory plant saponins: characteristics and biotechnological approaches towards sustainable production

F De Costa, A CA Yendo, JD Fleck… - Mini Reviews in …, 2011 - ingentaconnect.com
Saponins can be classified as triterpenoid (C30) or steroidal (C27), based on their carbon
nucleus (aglycone). Sugar residues are linked to the aglycone, conferring an amphiphilic …

Saponins regulate intestinal inflammation in colon cancer and IBD

J Dong, W Liang, T Wang, J Sui, J Wang, Z Deng… - Pharmacological …, 2019 - Elsevier
The saponins are natural surface-active glycosides which are the principal components of
many popular herbal medicinal plants such as ginseng, astragalus, and bupleurum. Recent …

[HTML][HTML] Enhancement of an In Vivo Anti-Inflammatory Activity of Oleanolic Acid through Glycosylation Occurring Naturally in Stauntonia hexaphylla

LB Vinh, NTM Nguyet, L Ye, G Dan, NV Phong… - Molecules, 2020 - mdpi.com
Stauntonia hexaphylla (Lardizabalaceae) has been used as a traditional herbal medicine in
Korea and China for its anti-inflammatory and analgesic properties. As part of a …