To obtain a comprehensive picture of composite genetic driver events and clonal dynamics
in subtypes of paediatric acute lymphoblastic leukaemia (ALL) we analysed tumour-normal …

Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable
heterogeneity in initial diagnosis, with multiple (sub) clones harboring lesions in relapse …

Until recently, our understanding of the genetic factors contributing to the pathogenesis of
acute lymphoblastic leukemia (ALL) has relied on the detection of gross chromosomal …

Genomic characterization of pediatric acute lymphoblastic leukemia (ALL) has identified
distinct patterns of genes and pathways altered in patients with well‐defined genetic …

The mechanisms driving clonal heterogeneity and evolution in relapsed pediatric acute
lymphoblastic leukemia (ALL) are not fully understood. We performed whole genome …

There is incomplete understanding of genetic heterogeneity and clonal evolution during
cancer progression. Here we use deep whole-exome sequencing to describe the clonal …

Over the past two decades, hematologic malignancies have been extensively evaluated due
to the introduction of powerful technologies, such as conventional karyotyping, FISH …

A key goal in cancer research is to identify the total complement of genetic and epigenetic
alterations that contribute to tumorogenesis. We are currently witnessing the rapid evolution …

Acute lymphoblastic leukaemia (ALL) is the commonest childhood cancer and an important
cause of morbidity from haematological malignancies in adults. In the past several years, we …

Despite recent progress in identifying the genetic drivers of acute lymphoblastic leukemia
(ALL), prognosis remains poor for those individuals who experience disease recurrence …