Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …

Natural product-inspired compound collections serve as excellent sources for the
identification of new bioactive compounds to treat disease. However, such compounds must …

Due to the importance of the amino ketone motif in synthetic and medicinal chemistry, the
number of protocols developed in recent years has considerably increased. This review …

Natural products (NPs) have been shown to be an extraordinary source of bioactive
compounds and three-dimensional complex frameworks that can be useful to produce high …

Many natural products of biological interest contain [6, 5]-and [6, 6]-spiroketal moieties that
can adopt various configurations, benefiting or not from anomeric conformation stabilizing …

Recent applications of seven-membered rings in drug design - ScienceDirect Skip to main
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Heteroatoms constitute a very common fragment of a number of active pharmaceutical
ingredients as well as excipients; from the point of view of significance, it is all the same if …

Aromatic heterocycles with basic nitrogen atoms as well as carboxylic acid derivatives are
the dominating chemical space in the universe of drug‐like molecules. These established …

Conspectus Enamine and enol ethers are nucleophilic functional groups that are well known
to most chemists. When enamine or enol ethers are present in natural products, they are …