Cells sense physical forces and convert them into electrical or chemical signals, a process
known as mechanotransduction. Whereas extensive studies focus on mechanotransduction …

OSCA/TMEM63s form mechanically activated (MA) ion channels in plants and animals,
respectively. OSCAs and related TMEM16s and transmembrane channel-like (TMC) …

Mechanotransduction has an important role in physiology. Biological processes including
sensing touch and sound waves require as-yet-unidentified cation channels that detect …

Neuronal mechano-sensitivity relies on mechano-gated ion channels, but pathways
regulating their activity remain poorly understood. TMEM150C was proposed to mediate …

▪ Abstract Mechanosensation has been studied for decades, but understanding of its
molecular mechanism is only now emerging from studies in Caenorhabditis elegans and …

Touch sensitivity in animals relies on nerve endings in the skin that convert mechanical force
into electrical signals. In the nematode Caenorhabditis elegans, gentle touch to the body …

Mechanotransduction is the process by which a mechanical force, such as touch, is
converted into an electrical signal. Transmembrane channel-like (TMC) proteins are an …

The ability to sense physical forces is conserved across all organisms. Cells convert
mechanical stimuli into electrical or chemical signals via mechanically activated ion …

Mechanosensory transduction in touch receptor neurons is believed to be mediated by
DEG/ENaC (degenerin/epithelial Na+ channel) proteins in nematodes and mammals. In the …

Mechanosensitive (MS) ion channels are a ubiquitous type of molecular force sensor
sensing forces from the surrounding bilayer. The profound structural diversity in these …