Effective and safe treatment of auditory and vestibular diseases has become increasingly
dependent on inner ear drug delivery systems. This review highlights recent advances in …

Many inner ear disorders cannot be adequately treated by systemic drug delivery. A blood-
cochlear barrier exists, similar physiologically to the blood-brain barrier, which limits the …

Numerous disease processes cause inner ear dysfunction and represent an opportunity for
therapeutic intervention. Hearing loss is the common endpoint of many inner ear disorders …

For many years, drug delivery to the inner ear has been a challenge to physicians in the
treatment of inner ear disorders. In the past decade, the field of inner ear drug delivery has …

Drug delivery to the inner ear is an ideal method to treat a wide variety of otologic conditions.
A broad range of potential applications is just beginning to be explored. New approaches …

Most therapies for treating sensorineural hearing loss are challenged by the delivery across
multiple tissue barriers to the hard-to-access anatomical location of the inner ear. In this …

Despite significant advances in the development of therapeutics for hearing loss, drug
delivery to the middle and inner ear remains a challenge. As conventional oral or …

The inner ear represents one of the most technologically challenging targets for local drug
delivery, but its clinical significance is rapidly increasing. The prevalence of sensorineural …

Inner ear diseases are not adequately treated by systemic drug administration mainly
because of the blood–perilymph barrier that reduces exchanges between plasma and inner …

Objectives The treatment of inner ear disorders remains challenging due to anatomic
barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent …