Background Studying human germ cell development and male infertility is heavily relied on
mouse models. In vitro differentiation of human pluripotent stem cells into spermatogonial …

Objectives This study is designed to generate and propagate human spermatogonial stem
cells (SSCs) derived from human pluripotent stem cells (hPSCs). Methods hPSCs were …

Generation of germ cells from pluripotent stem cells in vitro could have great application for
treating infertility and provides an excellent model for uncovering molecular mechanisms …

Due to differences across species, the mechanisms of cell fate decisions determined in mice
cannot be readily extrapolated to humans. In this study, we developed a feeder-and xeno …

Spermatogenic lineage has been directly generated in spermatogonial stem cell (SSC)
conditions from human pluripotent stem cells (PSCs). However, it remains unknown whether …

Background Depletion of oocytes leads to ovarian aging-associated infertility, endocrine
disruption and related diseases. Excitingly, unlimited oocytes can be generated by …

Infertility is defined as not being able to become pregnant or to conceive a child after one
year or longer of regular unprotected intercourse. Male infertility refers to a male's inability to …

The in vitro derivation and propagation of spermatogonial stem cells (SSCs) from pluripotent
stem cells (PSCs) is a key goal in reproductive science. We show here that when …

Recent studies have reported that induced pluripotent stem (iPS) cells from mice and
humans can differentiate into primordial germ cells. However, whether iPS cells are capable …

Male germ-cell development comprises primordial germ-cell (PGC) development,
spermatogonium differentiation, and ensuing spermatogenesis. We present a step-by-step …