Modulation of human mesenchymal and pluripotent stem cell behavior using biophysical and biochemical cues: A review

S Ding, P Kingshott, H Thissen, M Pera… - Biotechnology and …, 2017 - Wiley Online Library
In vitro manipulation of human stem cells is a critical process in regenerative medicine and
cellular therapies. Strategies and methods to maintain stem cells and direct them into …

Direct control of stem cell behavior using biomaterials and genetic factors

JK Yoon, ML Kang, JH Park, KM Lee… - Stem Cells …, 2018 - Wiley Online Library
Stem cells have recently emerged as an important candidate for cell therapy. However,
some major limitations still exist such as a small quantity of cell supply, senescence, and …

Engineered microenvironments for self-renewal and musculoskeletal differentiation of stem cells

Y Hwang, A Phadke, S Varghese - Regenerative medicine, 2011 - Taylor & Francis
Stem cells hold great promise for therapies aimed at regenerating damaged tissue, drug
screening and studying in vitro models of human disease. However, many challenges …

Maintenance and modulation of stem cells stemness based on biomaterial designing via chemical and physical signals

C Zhao, K Lin, X Wang - Applied Materials Today, 2020 - Elsevier
Pluripotent stem cells have the ability of self-renewal and pluripotency, which makes them
promising for application in cell therapy, tissue engineering and regenerative medicine …

Modulation of human multipotent and pluripotent stem cells using surface nanotopographies and surface-immobilised bioactive signals: A review

PY Wang, H Thissen, P Kingshott - Acta biomaterialia, 2016 - Elsevier
The ability to control the interactions of stem cells with synthetic surfaces is proving to be
effective and essential for the quality of passaged stem cells and ultimately the success of …

High throughput approaches for controlled stem cell differentiation

HD Kim, EA Lee, YH Choi, YH An, RH Koh, SL Kim… - Acta Biomaterialia, 2016 - Elsevier
Stem cells have unique ability to undergo self-renewal indefinitely in culture and potential to
differentiate into almost all cell types in the human body. However, the developing a method …

Human pluripotent stem cell mechanobiology: manipulating the biophysical microenvironment for regenerative medicine and tissue engineering applications

RG Ireland, CA Simmons - Stem Cells, 2015 - academic.oup.com
A stem cell in its microenvironment is subjected to a myriad of soluble chemical cues and
mechanical forces that act in concert to orchestrate cell fate. Intuitively, many of these …

Concise review: stem cell microenvironment on a chip: current technologies for tissue engineering and stem cell biology

DY Park, J Lim, JY Park, SH Lee - Stem cells translational …, 2015 - academic.oup.com
Stem cells have huge potential in many therapeutic areas. With conventional cell culture
methods, however, it is difficult to achieve in vivo-like microenvironments in which a number …

Biomaterial engineering for controlling pluripotent stem cell fate

TB Bertucci, G Dai - Stem cells international, 2018 - Wiley Online Library
Pluripotent stem cells (PSCs) represent an exciting cell source for tissue engineering and
regenerative medicine due to their self‐renewal and differentiation capacities. The majority …

Physicochemical control of adult stem cell differentiation: shedding light on potential molecular mechanisms

I Titushkin, S Sun, J Shin, M Cho - BioMed Research …, 2010 - Wiley Online Library
Realization of the exciting potential for stem‐cell‐based biomedical and therapeutic
applications, including tissue engineering, requires an understanding of the cell‐cell and …