Hepatic stellate cells (HSCs) are resident non-parenchymal liver pericytes whose plasticity
enables them to regulate a remarkable range of physiologic and pathologic responses. To …

Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

Hepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve
numerous critical functions in the normal liver and in response to injury. HSCs are primarily …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Liver fibrosis is a regenerative process that occurs after injury. It is characterized by the
deposition of connective tissue by specialized fibroblasts and concomitant proliferative …

Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

The last decade has seen a rapid expansion in our understanding of the mechanisms
leading to hepatic stellate cell activation. The classic activation pathway of initiation …

Hepatic stellate cells (HSCs) are pericytes of liver in the space between parenchymal cells
and sinusoidal endothelial cells of the hepatic lobule. HSCs comprise specialized functions …

leading to an understanding that is increasingly nuanced. A clear example is the paper of
Magness and coworkers1 in this issue of HEPATOLOGY, which explores the topic of stellate …

Hepatic fibrosis is characterized by the pathological accumulation of extracellular matrix
(ECM) in the liver resulting from the persistent liver injury and wound-healing reaction …