The low-density lipoprotein receptor (LDLR) gene family includes LDLR, very LDLR, and
LDL receptor–related proteins (LRPs) such as LRP1, LRP1b (aka LRP-DIT), LRP2 (aka …

Background Recently, we and others have reported a causal role for oxidized lipids in the
pathogenesis of pulmonary hypertension (PH). However, the role of low‐density lipoprotein …

Pulmonary hypertension (PH) attributable to left heart disease (LHD) is believed to be the
most common form of PH and is strongly associated with increased mortality and morbidity …

Pulmonary hypertension (PH) is characterized by a thickening of the distal pulmonary
arteries caused by medial hypertrophy, intimal proliferation and vascular fibrosis. Low …

Rationale: Arterial remodeling—a hallmark of many cardiovascular pathologies including
pulmonary arterial hypertension (PAH)—is regulated by TGFβ1 (transforming growth factor …

The development of pulmonary hypertension (PH) is common and has adverse prognostic
implications in patients with heart failure due to left heart disease (LHD), and thus far, there …

Low-density lipoprotein receptor–related protein-1 (LRP1) is a large endocytic and signaling
receptor belonging to the LDL receptor (LDLR) gene family and that is widely expressed in …

The LDLR family of proteins is involved in lipoproteins trafficking. While the role of LDLR in
cardiovascular disease has been widely studied, only recently the role of other members of …

The low‐density lipoprotein (LDL) receptor is the founding member of a family of seven
structurally closely related transmembrane proteins (LRP1, LRP1b, megalin/LRP2, LDL …

The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a
large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of …