HIV-1 lethality and loss of Env protein expression induced by single synonymous substitutions in the virus genome intronic-splicing silencer
A Jordan-Paiz, M Nevot, K Lamkiewicz… - Journal of …, 2020 - Am Soc Microbiol
Synonymous genome recoding has been widely used to study different aspects of virus
biology. Codon usage affects the temporal regulation of viral gene expression. In this study …
biology. Codon usage affects the temporal regulation of viral gene expression. In this study …
Synonymous Codon Pair Recoding of the HIV-1 env Gene Affects Virus Replication Capacity
A Jordan-Paiz, S Franco, MA Martinez - Cells, 2021 - mdpi.com
Synonymous codon pair deoptimization is an efficient strategy for virus attenuation;
however, the underlying mechanism remains controversial. Here, we optimized and …
however, the underlying mechanism remains controversial. Here, we optimized and …
Identification of a novel splice acceptor in the HIV-1 genome: independent expression of the cytoplasmic tail of the envelope protein
B Berkhout, JLB Van Wamel - Archives of virology, 1996 - Springer
Multiple splicing sites exist in the RNA genome of the human immunodeficiency virus type 1
(HIV-1). In a screen for subgenomic forms of the HIV-1 genome that could be transferred to …
(HIV-1). In a screen for subgenomic forms of the HIV-1 genome that could be transferred to …
HIV-1 protease evolvability is affected by synonymous nucleotide recoding
One unexplored aspect of HIV-1 genetic architecture is how codon choice influences
population diversity and evolvability. Here we compared the levels of development of HIV-1 …
population diversity and evolvability. Here we compared the levels of development of HIV-1 …
Impact of synonymous genome recoding on the HIV life cycle
A Jordan-Paiz, S Franco, MA Martínez - Frontiers in Microbiology, 2021 - frontiersin.org
Synonymous mutations within protein coding regions introduce changes in DNA or
messenger (m) RNA, without mutating the encoded proteins. Synonymous recoding of virus …
messenger (m) RNA, without mutating the encoded proteins. Synonymous recoding of virus …
Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication
MA Takata, SJ Soll, A Emery, D Blanco-Melo… - PLoS …, 2018 - journals.plos.org
The~ 9.5 kilobase HIV-1 genome contains RNA sequences and structures that control many
aspects of viral replication, including transcription, splicing, nuclear export, translation …
aspects of viral replication, including transcription, splicing, nuclear export, translation …
An exonic splicing silencer downstream of the 3′ splice site A2 is required for efficient human immunodeficiency virus type 1 replication
JM Madsen, CM Stoltzfus - Journal of virology, 2005 - Am Soc Microbiol
Alternative splicing of the human immunodeficiency virus type 1 (HIV-1) genomic mRNA
produces more than 40 unique viral mRNA species, of which more than half remain …
produces more than 40 unique viral mRNA species, of which more than half remain …
A suboptimal 5'splice site downstream of HIV-1 splice site A1 is required for unspliced viral mRNA accumulation and efficient virus replication
JM Madsen, CM Stoltzfus - Retrovirology, 2006 - Springer
Background Inefficient alternative splicing of the human immunodeficiency virus type 1 (HIV-
1) primary RNA transcript results in greater than half of all viral mRNA remaining unspliced …
1) primary RNA transcript results in greater than half of all viral mRNA remaining unspliced …
Characterizing HIV-1 splicing by using next-generation sequencing
A Emery, S Zhou, E Pollom, R Swanstrom - Journal of virology, 2017 - Am Soc Microbiol
Full-length human immunodeficiency virus type 1 (HIV-1) RNA serves as the genome or as
an mRNA, or this RNA undergoes splicing using four donors and 10 acceptors to create over …
an mRNA, or this RNA undergoes splicing using four donors and 10 acceptors to create over …
Analysis of competing HIV-1 splice donor sites uncovers a tight cluster of splicing regulatory elements within exon 2/2b
AL Brillen, L Walotka, F Hillebrand, L Müller… - Journal of …, 2017 - Am Soc Microbiol
The HIV-1 accessory protein Vif is essential for viral replication by counteracting the host
restriction factor APOBEC3G (A3G), and balanced levels of both proteins are required for …
restriction factor APOBEC3G (A3G), and balanced levels of both proteins are required for …