Background Uncontrolled growth in solid breast cancer generates mechanical compression
that may drive the cancer cells into a more invasive phenotype, but little is known about how …

Cell migration and invasion are two essential processes during cancer metastasis.
Increasing evidence has shown that the Piezo1 channel is involved in mediating cell …

Mechanical interaction between cells–specifically distortion of tensional homeostasis-
emerged as an important aspect of breast cancer genesis and progression. We investigated …

Background: Mechanically gated PIEZO channels lead to an influx of cations, activation of
additional Ca2+ channels, and cell depolarization. This study aimed to investigate PIEZO2's …

Cancer metastasis is one of the leading causes of death worldwide, motivating research into
identifying new methods of preventing cancer metastasis. Recently there has been …

Mechanotransduction is a key determinant of tissue homeostasis and tumor progression. It is
driven by intercellular adhesions, cell contractility, and forces generated within the …

Mechanosensing is an integral part of many physiological processes including stem cell
differentiation, fibrosis, and cancer progression. Two major mechanosensing systems—focal …

Cells utilize calcium channels as one of the main signaling mechanisms to sense changes
in the extracellular space and convert these changes to intracellular signals. Calcium …

Cancer cells are subjected to fluid shear stress during passage through the venous and
lymphatic system. Caveolin-1 (Cav-1), a principal structural component of caveolar …

Aims Mechanical forces surrounding solid tumors are pervasive in the tumor
microenvironment (TME) and abnormally altered as solid tumors progress. Although it has …