Mohawk is a transcription factor that promotes meniscus cell phenotype and tissue repair and reduces osteoarthritis severity

KI Lee, R Gamini, M Olmer, Y Ikuta, J Hasei… - Science translational …, 2020 - science.org
Meniscus tears are common knee injuries and a major osteoarthritis (OA) risk factor.
Knowledge gaps that limit the development of therapies for meniscus injury and …

Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation

H Nakahara, A Hasegawa, K Otabe… - Arthritis & …, 2013 - Wiley Online Library
Objective To investigate the expression and function of Mohawk (MKX) in human adult
anterior cruciate ligament (ACL) tissue and ligament cells from normal and osteoarthritis …

[HTML][HTML] The Mohawk homeobox gene represents a marker and osteo-inhibitory factor in calvarial suture osteoprogenitor cells

Y Wang, Q Qin, Z Wang, S Negri, T Sono… - Cell Death & …, 2024 - nature.com
The regeneration of the mammalian skeleton's craniofacial bones necessitates the action of
intrinsic and extrinsic inductive factors from multiple cell types, which function hierarchically …

Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGFβ signaling pathway

H Liu, C Zhang, S Zhu, P Lu, T Zhu, X Gong… - Stem …, 2015 - academic.oup.com
Abstract The transcription factor Mohawk (Mkx) is expressed in developing tendons and is
an important regulator of tenogenic differentiation. However, the exact roles of Mkx in …

[HTML][HTML] The Mkx homeoprotein promotes tenogenesis in stem cells and improves tendon repair

C Milet, D Duprez - Annals of translational medicine, 2015 - ncbi.nlm.nih.gov
Tendons are essential structures that transmit mechanical forces generated by skeletal
muscles to bones to cause body motion. Acute tendon injury and tendinopathy are common …

Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis

H Suzuki, Y Ito, M Shinohara… - Proceedings of the …, 2016 - National Acad Sciences
Cell-based or pharmacological approaches for promoting tendon repair are currently not
available because the molecular mechanisms of tendon development and healing are not …

The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates

N Onizuka, Y Ito, M Inagawa, H Nakahara… - Journal of Orthopaedic …, 2014 - Elsevier
Abstract Background Mohawk (Mkx) is a homeodomain-containing transcription factor that is
expressed in various mesoderm-derived tissues, particularly in developing tendons. In this …

[HTML][HTML] Dual roles of misshapen/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGFβ signaling

D Yu, J Hu, Z Sheng, G Fu, Y Wang, Y Chen… - Osteoarthritis and …, 2020 - Elsevier
Objective To identify the role of misshapen/NIK-related kinase (MINK1) in age-related
Osteoarthritis (OA) and injury-induced OA, and the effects of enhanced TGFβ signaling in …

Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo

K Otabe, H Nakahara, A Hasegawa… - Journal of …, 2015 - Wiley Online Library
Mohawk homeobox (MKX) has been demonstrated as a tendon/ligament specific
transcription factor. The aim of this study was to investigate the role of MKX in …

The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament

N Koda, T Sato, M Shinohara, S Ichinose, Y Ito… - …, 2017 - journals.biologists.com
The periodontal ligament (PDL), which connects the teeth to the alveolar bone, is essential
for periodontal tissue homeostasis. Although the significance of the PDL is recognized …