Mohawk is a transcription factor that promotes meniscus cell phenotype and tissue repair and reduces osteoarthritis severity
KI Lee, R Gamini, M Olmer, Y Ikuta, J Hasei… - Science translational …, 2020 - science.org
Meniscus tears are common knee injuries and a major osteoarthritis (OA) risk factor.
Knowledge gaps that limit the development of therapies for meniscus injury and …
Knowledge gaps that limit the development of therapies for meniscus injury and …
Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation
H Nakahara, A Hasegawa, K Otabe… - Arthritis & …, 2013 - Wiley Online Library
Objective To investigate the expression and function of Mohawk (MKX) in human adult
anterior cruciate ligament (ACL) tissue and ligament cells from normal and osteoarthritis …
anterior cruciate ligament (ACL) tissue and ligament cells from normal and osteoarthritis …
[HTML][HTML] The Mohawk homeobox gene represents a marker and osteo-inhibitory factor in calvarial suture osteoprogenitor cells
Y Wang, Q Qin, Z Wang, S Negri, T Sono… - Cell Death & …, 2024 - nature.com
The regeneration of the mammalian skeleton's craniofacial bones necessitates the action of
intrinsic and extrinsic inductive factors from multiple cell types, which function hierarchically …
intrinsic and extrinsic inductive factors from multiple cell types, which function hierarchically …
Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGFβ signaling pathway
Abstract The transcription factor Mohawk (Mkx) is expressed in developing tendons and is
an important regulator of tenogenic differentiation. However, the exact roles of Mkx in …
an important regulator of tenogenic differentiation. However, the exact roles of Mkx in …
[HTML][HTML] The Mkx homeoprotein promotes tenogenesis in stem cells and improves tendon repair
C Milet, D Duprez - Annals of translational medicine, 2015 - ncbi.nlm.nih.gov
Tendons are essential structures that transmit mechanical forces generated by skeletal
muscles to bones to cause body motion. Acute tendon injury and tendinopathy are common …
muscles to bones to cause body motion. Acute tendon injury and tendinopathy are common …
Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis
Cell-based or pharmacological approaches for promoting tendon repair are currently not
available because the molecular mechanisms of tendon development and healing are not …
available because the molecular mechanisms of tendon development and healing are not …
The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates
N Onizuka, Y Ito, M Inagawa, H Nakahara… - Journal of Orthopaedic …, 2014 - Elsevier
Abstract Background Mohawk (Mkx) is a homeodomain-containing transcription factor that is
expressed in various mesoderm-derived tissues, particularly in developing tendons. In this …
expressed in various mesoderm-derived tissues, particularly in developing tendons. In this …
[HTML][HTML] Dual roles of misshapen/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGFβ signaling
Objective To identify the role of misshapen/NIK-related kinase (MINK1) in age-related
Osteoarthritis (OA) and injury-induced OA, and the effects of enhanced TGFβ signaling in …
Osteoarthritis (OA) and injury-induced OA, and the effects of enhanced TGFβ signaling in …
Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo
K Otabe, H Nakahara, A Hasegawa… - Journal of …, 2015 - Wiley Online Library
Mohawk homeobox (MKX) has been demonstrated as a tendon/ligament specific
transcription factor. The aim of this study was to investigate the role of MKX in …
transcription factor. The aim of this study was to investigate the role of MKX in …
The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament
N Koda, T Sato, M Shinohara, S Ichinose, Y Ito… - …, 2017 - journals.biologists.com
The periodontal ligament (PDL), which connects the teeth to the alveolar bone, is essential
for periodontal tissue homeostasis. Although the significance of the PDL is recognized …
for periodontal tissue homeostasis. Although the significance of the PDL is recognized …