Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning

WB Bruin, P Zhutovsky, GA van Wingen… - Nature Mental …, 2024 - nature.com
Neuroanatomical findings on youth anxiety disorders are notoriously difficult to replicate,
small in effect size and have limited clinical relevance. These concerns have prompted a …

A Computational Network Perspective on Pediatric Anxiety

R Abend, M Bajaj, D Coppersmith… - Biological …, 2020 - biologicalpsychiatryjournal.com
Background Psychiatric taxonomy segregates pediatric anxiety symptoms into distinct
diagnostic subtypes. However, typical mixed symptom presentation poses significant …

Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety

SJ Zacharek, S Kribakaran, ER Kitt, DG Gee - Developmental Cognitive …, 2021 - Elsevier
Anxiety disorders are the most prevalent psychiatric condition among youth, with symptoms
commonly emerging prior to or during adolescence. Delineating neurodevelopmental …

Neuroanatomical subtyping of phobias: implications for function and development

PA Kirk, OJ Robinson - American Journal of Psychiatry, 2024 - psychiatryonline.org
Anxiety disorders are the most common of mental illnesses (1), yet their pathophysiology
remains poorly understood. Despite over two decades of neuroimaging research, which has …

A biomarker discovery framework for childhood anxiety

WJ Bosl, M Bosquet Enlow, EF Lock… - Frontiers in Psychiatry, 2023 - frontiersin.org
Introduction Anxiety is the most common manifestation of psychopathology in youth,
negatively affecting academic, social, and adaptive functioning and increasing risk for …

Toward robust anxiety biomarkers: a machine learning approach in a large-scale sample

EA Boeke, AJ Holmes, EA Phelps - Biological Psychiatry: Cognitive …, 2020 - Elsevier
Background The field of psychiatry has long sought biomarkers that can objectively
diagnose patients, predict treatment response, or identify individuals at risk of illness onset …

Neuroanatomic abnormalities in adolescents with generalized anxiety disorder: A voxel‐based morphometry study

JR Strawn, AM Wehry, WJ Chu, CM Adler… - Depression and …, 2013 - Wiley Online Library
Background Despite recent data implicating functional abnormalities in the neurocircuitry
underlying emotional processing in pediatric anxiety disorders, little is known regarding …

[HTML][HTML] Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults

S Xie, X Zhang, W Cheng, Z Yang - General Psychiatry, 2021 - ncbi.nlm.nih.gov
Adolescence is the peak period for the incidence of anxiety disorders. Recent findings have
revealed the immaturity of neural networks underlying emotional regulation in this …

Neurobiology of pediatric anxiety disorders

JR Strawn, KC Dominick, LR Patino, CD Doyle… - Current behavioral …, 2014 - Springer
While the fear-based anxiety disorders (ie, generalized anxiety disorder, social phobia and
separation anxiety disorder) are among the most common psychiatric conditions in children …

Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders

R Ge, R Sassi, LN Yatham, S Frangou - Molecular Psychiatry, 2023 - nature.com
Mood and anxiety disorders typically begin in adolescence and have overlapping clinical
features but marked inter-individual variation in clinical presentation. The use of multimodal …