CotB2 catalyzes the first committed step in cyclooctatin biosynthesis of the soil bacterium
Streptomyces melanosporofaciens. To date, CotB2 represents the best studied bacterial …

Terpene cyclases are responsible for the initial cyclization cascade in the multistep
synthesis of a large number of terpenes. CotB2 is a diterpene cyclase from Streptomyces …

Structural diversity of diterpenes is mediated by the enigmatic family of diterpene synthases.
The overall enzymatic contribution hereby lies in a carefully concerted chemistry of highly …

Sesquiterpenes and diterpenes are a diverse class of secondary metabolites that are
predominantly derived from plants and some prokaryotes. The properties of these natural …

The structural diversity of bioactive diterpenes is due to variations in their macrocyclic
carbon skeletons. The chemical synthesis of these macrocycles is challenging. However, the …

Terpenes constitute the largest and structurally most diverse natural product family. Most
terpenoids exhibit a stereochemically complex macrocyclic core, which is generated by C–C …

Two homologs of the diterpene synthase CotB2 from Streptomyces collinus (ScCotB2) and
Streptomyces iakyrus (SiCotB2) were investigated for their products by in vitro incubations of …

Terpenoids, which are also known as isoprenoids, are a large and highly diverse group of
natural products.[1–3] The structural diversity of terpenoids is a result of the cyclization of a …

Terpenoids are the largest family of natural products, but prokaryotes are vastly
underrepresented in this chemical space. However, genomics supports vast untapped …

Covering: up to 2015 This review summarises the accumulated knowledge about
characterised bacterial terpene cyclases. The structures of identified products and of …