Molecular and cellular basis of cardiovascular gender differences

ME Mendelsohn, RH Karas - Science, 2005 - science.org
Cardiovascular diseases (CVDs), the major cause of morbidity and mortality for both men
and women, occur uncommonly in premenopausal women, but their incidence rises sharply …

Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease

AC Boese, SC Kim, KJ Yin, JP Lee… - American Journal of …, 2017 - journals.physiology.org
Sex differences between women and men are often overlooked and underappreciated when
studying the cardiovascular system. It has been long assumed that men and women are …

Sex-specific physiology and cardiovascular disease

CL Shufelt, C Pacheco, MS Tweet, VM Miller - Sex-Specific Analysis of …, 2018 - Springer
Sex differences in cardiovascular diseases can be classified as those which are specific to
one sex and those that differ in incidence, prevalence, etiology, symptomatology, response …

Women-specific factors to consider in risk, diagnosis and treatment of cardiovascular disease

RE Harvey, KE Coffman, VM Miller - Women's Health, 2015 - journals.sagepub.com
In the era of individualized medicine, gaps in knowledge remain about sex-specific risk
factors, diagnostic and treatment options that might reduce mortality from cardiovascular …

Gender-based research underscores sex differences in biological processes, clinical disorders and pharmacological interventions

SR Bernstein, C Kelleher, RA Khalil - Biochemical Pharmacology, 2023 - Elsevier
Earlier research has presumed that the male and female biology is similar in most organs
except the reproductive system, leading to major misconceptions in research interpretations …

Mechanistic pathways of sex differences in cardiovascular disease

V Regitz-Zagrosek, G Kararigas - Physiological reviews, 2016 - journals.physiology.org
Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …

Therapeutic implications of the gender-specific aspects of cardiovascular disease

V Regitz-Zagrosek - Nature reviews Drug discovery, 2006 - nature.com
The manifestations of cardiovascular diseases differ between men and women, as do
outcomes after therapeutic interventions. It is important that those involved in drug discovery …

Illuminating the mechanisms underlying sex differences in cardiovascular disease

K Reue, CB Wiese - Circulation research, 2022 - Am Heart Assoc
Sex is a key risk factor for many types of cardiovascular disease. It is imperative to
understand the mechanisms underlying sex differences to devise optimal preventive and …

Sex/gender medicine the biological basis for personalized care in cardiovascular medicine

FA Arain, FH Kuniyoshi, AD Abdalrhim… - Circulation Journal, 2009 - jstage.jst.go.jp
Sex differences in morbidity and mortality associated with cardiovascular disease have been
recognized by the medical community for decades. Investigation into the underlying …

Atherosclerosis and sex hormones: current concepts

AC Villablanca, M Jayachandran, C Banka - Clinical science, 2010 - portlandpress.com
CVD (cardiovascular disease) is the leading cause of death for women. Considerable
progress has been made in both our understanding of the complexities governing …