Can we predict tuberculosis cure? What tools are available?
Antibiotic treatment of tuberculosis takes≥ 6 months, putting a major burden on patients and
health systems in large parts of the world. Treatment beyond 2 months is needed to prevent …
health systems in large parts of the world. Treatment beyond 2 months is needed to prevent …
Biomarkers of disease activity, cure, and relapse in tuberculosis
Although what actually constitutes tuberculosis might seem obvious—disease arising from
infection by members of the Mycobacterium tuberculosis complex(primarily but not …
infection by members of the Mycobacterium tuberculosis complex(primarily but not …
Defining outcomes of tuberculosis (treatment): from the past to the future
G Günther, J Heyckendorf, JP Zellweger, M Reimann… - Respiration, 2021 - karger.com
Untreated active tuberculosis (TB) has a very high long-term mortality. Treatment of TB
reduces mortality dramatically and should maximize cure, preventing ongoing transmission …
reduces mortality dramatically and should maximize cure, preventing ongoing transmission …
Assessment of treatment response in tuberculosis
N Rockwood, E du Bruyn, T Morris… - Expert review of …, 2016 - Taylor & Francis
Antibiotic treatment of tuberculosis has a duration of several months. There is significant
variability of the host immune response and the pharmacokinetic-pharmacodynamic …
variability of the host immune response and the pharmacokinetic-pharmacodynamic …
Biomarkers for tuberculosis disease activity, cure, and relapse
RS Wallis, TM Doherty, P Onyebujoh… - The Lancet infectious …, 2009 - thelancet.com
New drugs, vaccines, and other therapies will be required to realise the goal of global
tuberculosis elimination or control. This Review covers the important role biomarkers can …
tuberculosis elimination or control. This Review covers the important role biomarkers can …
Biomarkers that correlate with active pulmonary tuberculosis treatment response: a systematic review and meta-analysis
AJ Zimmer, F Lainati, N Aguilera Vasquez… - Journal of clinical …, 2022 - Am Soc Microbiol
Current WHO recommendations for monitoring treatment response in adult pulmonary
tuberculosis (TB) are sputum smear microscopy and/or culture conversion at the end of the …
tuberculosis (TB) are sputum smear microscopy and/or culture conversion at the end of the …
[HTML][HTML] Tuberculosis biomarkers: from diagnosis to protection
New approaches to control tuberculosis (TB) worldwide are needed. In particular, new tools
for diagnosis and new biomarkers are required to evaluate both pathogen and host key …
for diagnosis and new biomarkers are required to evaluate both pathogen and host key …
[HTML][HTML] Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial
Background: By the early 1980s, tuberculosis treatment was shortened from 24 to 6 months,
maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have …
maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have …
Tuberculosis treatment monitoring and outcome measures: new interest and new strategies
J Heyckendorf, SB Georghiou, N Frahm… - Clinical microbiology …, 2022 - Am Soc Microbiol
Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a
global public health threat. A significant challenge for TB control efforts has been the …
global public health threat. A significant challenge for TB control efforts has been the …
Biomarkers of tuberculosis severity and treatment effect: a directed screen of 70 host markers in a randomized clinical trial
GB Sigal, MR Segal, A Mathew, L Jarlsberg, M Wang… - …, 2017 - thelancet.com
More efficacious treatment regimens are needed for tuberculosis, however, drug
development is impeded by a lack of reliable biomarkers of disease severity and of …
development is impeded by a lack of reliable biomarkers of disease severity and of …