Antibiotic treatment of tuberculosis takes≥ 6 months, putting a major burden on patients and
health systems in large parts of the world. Treatment beyond 2 months is needed to prevent …

Although what actually constitutes tuberculosis might seem obvious—disease arising from
infection by members of the Mycobacterium tuberculosis complex(primarily but not …

Untreated active tuberculosis (TB) has a very high long-term mortality. Treatment of TB
reduces mortality dramatically and should maximize cure, preventing ongoing transmission …

Antibiotic treatment of tuberculosis has a duration of several months. There is significant
variability of the host immune response and the pharmacokinetic-pharmacodynamic …

New drugs, vaccines, and other therapies will be required to realise the goal of global
tuberculosis elimination or control. This Review covers the important role biomarkers can …

Current WHO recommendations for monitoring treatment response in adult pulmonary
tuberculosis (TB) are sputum smear microscopy and/or culture conversion at the end of the …

New approaches to control tuberculosis (TB) worldwide are needed. In particular, new tools
for diagnosis and new biomarkers are required to evaluate both pathogen and host key …

Background: By the early 1980s, tuberculosis treatment was shortened from 24 to 6 months,
maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have …

Despite the advent of new diagnostics, drugs and regimens, tuberculosis (TB) remains a
global public health threat. A significant challenge for TB control efforts has been the …

More efficacious treatment regimens are needed for tuberculosis, however, drug
development is impeded by a lack of reliable biomarkers of disease severity and of …