Macrophage polarization in chronic inflammatory diseases: killers or builders?

L Parisi, E Gini, D Baci, M Tremolati… - Journal of …, 2018 - Wiley Online Library
Macrophages are key cellular components of the innate immunity, acting as the main player
in the first‐line defence against the pathogens and modulating homeostatic and …

Implications of macrophage polarization in autoimmunity

SC Funes, M Rios, J Escobar‐Vera, AM Kalergis - Immunology, 2018 - Wiley Online Library
Macrophages are extremely heterogeneous and plastic cells with an important role not only
in physiological conditions, but also during inflammation (both for initiation and resolution) …

[HTML][HTML] The role of macrophage polarization in infectious and inflammatory diseases

AC Labonte, AC Tosello-Trampont, YS Hahn - Molecules and cells, 2014 - Elsevier
Macrophages, found in circulating blood as well as integrated into several tissues and
organs throughout the body, represent an important first line of defense against disease and …

[HTML][HTML] Ontogeny and polarization of macrophages in inflammation: blood monocytes versus tissue macrophages

A Dey, J Allen, PA Hankey-Giblin - Frontiers in immunology, 2015 - frontiersin.org
The explosion of new information in recent years on the origin of macrophages in the steady-
state and in the context of inflammation has opened up numerous new avenues of …

Macrophage polarization in health and disease

L Cassetta, E Cassol, G Poli - The Scientific World Journal, 2011 - Wiley Online Library
Macrophages are terminally differentiated cells of the mononuclear phagocyte system that
also encompasses dendritic cells, circulating blood monocytes, and committed myeloid …

Macrophage polarization in pathology

A Sica, M Erreni, P Allavena, C Porta - Cellular and molecular life sciences, 2015 - Springer
Macrophages are cells of the innate immunity constituting the mononuclear phagocyte
system and endowed with remarkable different roles essential for defense mechanisms …

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

D Zhou, C Huang, Z Lin, S Zhan, L Kong, C Fang, J Li - Cellular signalling, 2014 - Elsevier
Monocytes/macrophages are heterogeneous and versatile cells that could undergo their
phenotypically/functionally dynamic switch in response to the microenvironment signals …

[HTML][HTML] Macrophage polarization in inflammatory diseases

YC Liu, XB Zou, YF Chai, YM Yao - International journal of …, 2014 - ncbi.nlm.nih.gov
Diversity and plasticity are two hallmarks of macrophages. M1 macrophages (classically
activated macrophages) are pro-inflammatory and have a central role in host defense …

[HTML][HTML] Targeting macrophages: friends or foes in disease?

JA Ardura, G Rackov, E Izquierdo, V Alonso… - Frontiers in …, 2019 - frontiersin.org
Macrophages occupy a prominent position during immune responses. They are considered
the final effectors of any given immune response since they can be activated by a wide …

Macrophage plasticity, polarization, and function in health and disease

A Shapouri‐Moghaddam… - Journal of cellular …, 2018 - Wiley Online Library
Macrophages are heterogeneous and their phenotype and functions are regulated by the
surrounding micro‐environment. Macrophages commonly exist in two distinct subsets: 1) …