NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in Hypertension

J Krishnan, EM Hennen, M Ao, A Kirabo… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: Neutrophil extracellular traps (NETs) are composed of DNA, enzymes, and
citrullinated histones that are expelled by neutrophils in the process of NETosis. NETs …

Arterial hypertension enhances neutrophil extracellular trap formation via an angiotensin-II-dependent pathway

T Hofbauer, T Scherz, J Müller, H Heidari… - …, 2017 - atherosclerosis-journal.com
Aim: By expelling their nuclear content into the extracellular space, neutrophil granulocytes
form neutrophil extracellular traps (NETs) in order to entrap and neutralize pathogens …

Neutrophil extracellular traps accelerate vascular smooth muscle cell proliferation via Akt/CDKN1b/TK1 accompanying with the occurrence of hypertension

X Fang, L Ma, Y Wang, F Ren, Y Yu, Z Yuan… - Journal of …, 2022 - journals.lww.com
Objective: Neutrophil extracellular traps (NETs) can trigger pathological changes in vascular
cells or vessel wall components, which are vascular pathological changes of hypertension …

A perspective on NETosis in diabetes and cardiometabolic disorders

GP Fadini, L Menegazzo, V Scattolini, M Gintoli… - Nutrition, Metabolism …, 2016 - Elsevier
Aims To review the significance of a new type of neutrophil cell death (NETosis) in diabetes
and cardiometabolic diseases. Data synthesis Diabetes and the metabolic syndrome are …

NETosis in ischemic/reperfusion injuries: An organ-based review

P Hashemi, M Nouri-Vaskeh, L Alizadeh… - Life Sciences, 2022 - Elsevier
Neutrophil extracellular trap (NETosis), the web-like structures induced by neutrophil death,
is an important inflammatory mechanism of the immune system leading to reactive oxygen …

Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice

C Liu, S Yalavarthi, A Tambralli, L Zeng… - Science …, 2023 - science.org
While neutrophil extracellular traps (NETs) have previously been linked to some diabetes-
associated complications, such as dysfunctional wound healing, their potential role in …

[HTML][HTML] Neutrophil elastase‐deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis

K Martinod, T Witsch, K Farley, M Gallant… - Journal of Thrombosis …, 2016 - Elsevier
Essentials• Neutrophil elastase (NE) plays a role in extracellular trap formation (NETosis)
triggered by microbes.• The contribution of NE was evaluated in mouse NETosis models of …

Nets, pulmonary arterial hypertension, and thrombo-inflammation

LP Baptista de Barros Ribeiro Dourado… - Journal of Molecular …, 2022 - Springer
Pulmonary arterial hypertension (PAH) is a progressive and fatal vascular disease in which
high blood pressure in the pulmonary artery and remodeling of the pulmonary vasculature …

NET-(works) in arterial and venous thrombo-occlusive diseases

M Zdanyte, O Borst, P Münzer - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Formation of Neutrophil Extracellular Traps (NETosis), accompanied by the release of
extracellular decondensed chromatin and pro-inflammatory as well as pro-thrombotic …

Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide

R Loperena, JP Van Beusecum, HA Itani… - Cardiovascular …, 2018 - academic.oup.com
Aims Monocytes play an important role in hypertension. Circulating monocytes in humans
exist as classical, intermediate, and non-classical forms. Monocyte differentiation can be …